Overflow Metabolism: From Yeast to Marathon Runners
()
About this ebook
Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts.
This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage.
- Includes examples of overflow metabolism and major phenomenological features
- Features a critical view of proposed theories to explain overflow metabolism
- Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results
Alexei Vazquez
Alexei Vazquez began his studies in Physics at the University of Havana, where he obtained a BSc and MSc degrees in 1995 and 1997. In 2002 he obtained a PhD degree in Statistical and Biological Physics from the International School of Advanced Studies in Trieste. Subsequently, he held postdoctoral positions at the University of Notre Dame in Indiana and at the Institute for Advanced Study in Princeton. From 2009 to 2014, Dr. Vazquez was an Assistant Professor at The Cancer Institute of New Jersey. Since 2014 he is a group leader at the Cancer Research UK Beatson Institute in Glasgow. Dr.Vazquez research focuses on cancer metabolism, using theoretical and experimental methods.
Related to Overflow Metabolism
Related ebooks
Coconut Oil: Coconut Oil Diet Plan: Coconut Oil Cookbook and Coconut Oil Recipes to Lose Weight Naturally, Detox your Body and Feel Great Rating: 0 out of 5 stars0 ratingsGood Being, Good Living: The Modern Model for Sustained Holistic Health Rating: 0 out of 5 stars0 ratingsMy Life as a Shipping Container Rating: 0 out of 5 stars0 ratings6 Weeks to Better Adrenal Health and Fat Loss Rating: 0 out of 5 stars0 ratingsOvercome your Fear of Contact: A Training Program: In Seven Steps from Fear of Contact to a Social Butterfly Rating: 0 out of 5 stars0 ratingsAging Sucks... But You're Gonna Love It! Rating: 0 out of 5 stars0 ratingsThe Limitless Men Guide with 300 Hacks of AntiAging Epigenetic Biohacking Dating Finance Rating: 0 out of 5 stars0 ratingsNatural Skin Care Tips Rating: 0 out of 5 stars0 ratingsExpectant Father Rating: 0 out of 5 stars0 ratingsWeight Release: A Liberating Journey Rating: 0 out of 5 stars0 ratingsHow to Cure Acne Rating: 0 out of 5 stars0 ratingsPaleo Diet: Side Effects- Health Learning Series Rating: 5 out of 5 stars5/5Detoxify Your Body in 10 Days Rating: 0 out of 5 stars0 ratingsChemical Pathways of Metabolism Rating: 0 out of 5 stars0 ratingsBioenergetics: A Novel Theory for Atp Synthesis Rating: 0 out of 5 stars0 ratingsHow To Burn Fat Without Counting Calories: A Perfect Way for Weight Loss Rating: 0 out of 5 stars0 ratingsLose Weight the Healthy Way: Paleo Diet Recipes to Lose Weight Fast, Remove Cellulite, Boost Metabolism & Enjoy Your Life Rating: 0 out of 5 stars0 ratingsThe Man Who Lived Forever Rating: 0 out of 5 stars0 ratingsThe Nourishing Diet Rating: 0 out of 5 stars0 ratingsSuper Cleanse: Detox Your Body for Long-Lasting Health and Beauty Rating: 4 out of 5 stars4/5Varicocele Secrets: The Underground Solution for Getting Rid of Varicocele for The Rest of Your Life [EN] Rating: 0 out of 5 stars0 ratingsSugar: A Sweet Drug Rating: 5 out of 5 stars5/5Calm Mind Rating: 0 out of 5 stars0 ratingsYou Can Save Your Small Business, Turning Around the Troubled Small Business Rating: 0 out of 5 stars0 ratingsIntermittent Fasting Rating: 5 out of 5 stars5/530 Days to Lose Your Winter Weight Gain! Rating: 0 out of 5 stars0 ratings
Biology For You
Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5The Winner Effect: The Neuroscience of Success and Failure Rating: 5 out of 5 stars5/5The Soul of an Octopus: A Surprising Exploration into the Wonder of Consciousness Rating: 4 out of 5 stars4/5Why We Sleep: Unlocking the Power of Sleep and Dreams Rating: 4 out of 5 stars4/5The Sixth Extinction: An Unnatural History Rating: 4 out of 5 stars4/5Lifespan: Why We Age—and Why We Don't Have To Rating: 4 out of 5 stars4/5The Grieving Brain: The Surprising Science of How We Learn from Love and Loss Rating: 4 out of 5 stars4/5Mother of God: An Extraordinary Journey into the Uncharted Tributaries of the Western Amazon Rating: 4 out of 5 stars4/5Sapiens: A Brief History of Humankind Rating: 4 out of 5 stars4/5"Cause Unknown": The Epidemic of Sudden Deaths in 2021 & 2022 Rating: 5 out of 5 stars5/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness Rating: 4 out of 5 stars4/5Dopamine Detox: Biohacking Your Way To Better Focus, Greater Happiness, and Peak Performance Rating: 3 out of 5 stars3/5The Obesity Code: the bestselling guide to unlocking the secrets of weight loss Rating: 4 out of 5 stars4/5How Emotions Are Made: The Secret Life of the Brain Rating: 4 out of 5 stars4/5Lies My Gov't Told Me: And the Better Future Coming Rating: 4 out of 5 stars4/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5The Blood of Emmett Till Rating: 4 out of 5 stars4/5A Letter to Liberals: Censorship and COVID: An Attack on Science and American Ideals Rating: 3 out of 5 stars3/5Emotional Blackmail: When the People in Your Life Use Fear, Obligation, and Guilt to Manipulate You Rating: 4 out of 5 stars4/5Homo Deus: A Brief History of Tomorrow Rating: 4 out of 5 stars4/5A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution Rating: 4 out of 5 stars4/5Suicidal: Why We Kill Ourselves Rating: 4 out of 5 stars4/5The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race Rating: 4 out of 5 stars4/5The Unpersuadables: Adventures with the Enemies of Science Rating: 4 out of 5 stars4/5Anatomy 101: From Muscles and Bones to Organs and Systems, Your Guide to How the Human Body Works Rating: 4 out of 5 stars4/5Fantastic Fungi: How Mushrooms Can Heal, Shift Consciousness, and Save the Planet Rating: 5 out of 5 stars5/5Jaws: The Story of a Hidden Epidemic Rating: 4 out of 5 stars4/5The Deepest Well: Healing the Long-Term Effects of Childhood Trauma and Adversity Rating: 4 out of 5 stars4/5
Related categories
Reviews for Overflow Metabolism
0 ratings0 reviews
Book preview
Overflow Metabolism - Alexei Vazquez
manuscript.
Chapter 1
A Historical View of Overflow Metabolism
Abstract
Metabolism is the biological process where cells, tissues or whole organisms utilize organic molecules for survival, proliferation and to transform the environment. Metabolism is conceptually divided into catabolism and anabolism. Catabolism involves the breakdown of organic molecules to generate energy and precursor molecules for anabolism. Anabolism involves the synthesis of cell components from precursor molecules and energy. When catabolism is fully efficient, organic molecules are fully incorporated into the cell biomass or they are broken down to carbon dioxide to obtain the maximum energy yield. Under certain conditions, the organic molecules are only partially broken, and the products of incomplete catabolism are released to the environment. This phenomenon of incomplete catabolism, characterized by the excretion of metabolic products that could be otherwise incorporated in the cell biomass or catabolized to carbon dioxide, is called overflow