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Pharmacrystal

EUDARAGIT L & S are the enteric coating polymer......dissolves at pH 6 and 7 resp..

while EUDARAGIT RL & RS are the Non-enteric polymer

Plicamycin(mithramycin) is the only one antibiotic which used in hypercalcemia.

Denosumab is anti RANK Ligand antibody.

Morphine is a benzylisoquinoline alkaloid.Acts directly on the central nervous system (CNS) to

relieve pain (NSAIDs not act on CNS)

<PD Inhibitors>nonslective
PDI PDI 1 PDI 2 PDI 3 Theophylline,papaverin, vinpocetin (in vinca) not exist, amrinone,milrinone,cilastazol

read Microbial source & Assay fm Piyush book question may be ask this time in GPAT, read NMR&IR(ranges) frm pavia book HAART tretment;
2 NUCLLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR+ 1 NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OR 1 OR 2 PROTEASE

: Adenosin used in sup. vent tackycardia n Mg chloride used in digoxin toxicity... Amiodaron, Flecainide,Moricizine are used in WPW HPTLC is useful for both Qualitative and Quantitative use. Do all stomata type with example Affinity chrmatography mainly use for biological compound. It is based on 'lock and key'
mechanism.

Capsule of 000 size has highest filling capsule. neostigmine use to treat mysthenia gravis . Endrophonium use to test m.gravis & to distinguish from cholinergic crisis.

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Mutual prodrug is combination of 2 active compound.

For eg. Benorylate= Aspirine + Paracetamol.

Prodrug = Drug latentiation Drug cycling betwen intestine & liver is called as enterohepatic cycling of drug.It prolongs half life
of steroidal drugs & Hormones.

Biochemical tests:
Holander test:Insulin Foulget's test: Ketohexoses Tauber's test:Aldoentoses Do such tests from appendix of Satyanarayan

Major enzyme suppresors :

Erythromycin,Ketoconazole,Aspirin,MAO inhibitors,Cimetidine,Testosterone,Hydrocortisone,Corticosteroids.

PHENYTOIN:
hvng hydantoin ring in structure&bioeqvalance problm is due to poor water solublty&low therapeutic ratio.exhibit non linear p'cokonetinetics

pseudomonas diminuta&V.percolans r test organisms fr retention of 0.2micr

membrane.B.substilis is biological indcator fr eth.oxide sterilization

NIPER 2009 que.

Enzyme marker for Infective Hepatitis? Taxol's Chemical Name? configuration of ephedrine IR freq of acid chloride?

NIPER 2010 ques.

danosumab is used for which disease? which amino acid is derived from cadeverine? kupffer's cells are located in?

stomata;
coca,senna-paracytic vasaka,peppermint-diacytic eucalyptus,digitalis,lobelia-anomocytic all tropane alkaloid drugs-anisocytic

read azbout karl fisher titration in kasture(very imp.) drivers test is used dor testing efficiency of wetting agents. ( NIPER 2011 ) ephedra stem has stomata

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plz read ester hydrolysis mechanism table frm jerry march.eight mechanisms are given as table
one of them is frequently asked in NIPER JEE

Drug causes Stevan's Johnson syndrom-Antifungal azole, carbamazepine ,phenylbutazone,

sulfonamide,Lamotrigine, thiabendazole....

Terpens Biosynthsis

Terpens
mono & Di-\ sesque Tri Tetra poly

Products
Geranyl pyroPO4 ( GPP ) fernasyl pyroPO4 ( FPP ) squalene Geranyl geranial 3-methyl-3- butylpyroPO4

act on microtubules:Thibendazol,Mebendazol,Taxol,Griseofulvin,Vinca
,Colchicine..hepatotoxic:Na-valproate,paracetamol,halothane..

Gossypol is male Contraceptive,permethrin is natural insect repellent,Gymnema is natural

sweetner, Read Carbohydrate frm kokate book Indian Tragacanth Indian psylium Gelatine Gum Kariya Isabgol Gelatine

Examples
Atropine, Nicotine Conine, Lycopodine, piperidine indole Alka phenylethylamnine

Amino Acid
Ornithine lysine Tryptophan Tyrosin

AMIODARONE-aantiarrythmic & antianginal causes HYPOTHYROIDISM due 2 inhibit peripheral

convrtn of T4-T3

all organic nitrate except IOSORBIDE MONONITRATE undrgos extensive 1st pass
metabolism.denitrated by glutathion reductase,aldhyd dehydro

read 1-8 Chapter frm Satyanarayan book of Biochemestry, Rewise the Microbiology w8ever yu study in 2nd year, Do all tables frm lechman
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vit.A in high dose cause tertogenicity and its deficiency cause xeropthalmia and night blindness, burning feet syndrome-in pantothenic ac All opioids causes BRADYCARDIA exept MEPERIDINE, drug of choice in colic pain MORPHIN, trtmnt of methanol poisonig FOMEPEZOLE Hypersensitivity & antibody involved:
Type 1 Type 2 Type 3 Type 4 IgE IgG, Ig E IgG & IgM sensitise T-cell lymphocyte

drugs causing Gynaecomastia-(keep in mind as DISCO ):

Digoxin,Isoniazide,Spiranolactone,Cimetidine,Oestrogens..

Morphine caus Pinpoint pupil, Narcotic analgesic used in pregnancy is PETHEDINE, Streptomycine is triacidic&Tetracycline is Amphoteric nat Repaglinide & nateglinide stimtents Insulin secretion Thiazolidinedione(glitazone)-ci,tro,rosi,pio
(PPAR gamma recp) increses Insulin sensitive

MAJOR SUBJCTS 4 GPAT-pharmacognsy, med chem, cology, ceutics, analysis. MINOR SUBJCTS-microbio, bio chem, bio tech, organic, forensic, clinical. Amifostin has role in cisplatin nephrotoxicity,cisplatin most nephrotoxic among all Anticancer
drug,

what is Steal phenomenon streaming potential:-(in electrophoresis) the potential between two ends is called stremg potntal
do physical pharmacy from ALFRED MARTIN

Physical ph:- colligative properties depends on no. of particles in solution

e.g. osmotic pressure,B.P. elevation, freezing point depression

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Indinavir & Nelfinavir showed promising Antimalerial efficacy.Indinavir was found to synergise the
Antimalerial action of Artemisinin

osmotic Diuretic mannitol is used in CHF, Tachyphylaxis is associated with ephedrine Asthama is aggrevated by propanolol Adenosine and Histamine are the endogenous Anticonvolusants of the body,Pineapple contains
Bromelains which are Anti-inflamatory

Acetyl cysteine is used to prevent the paracetamol induced hepatotoxicity...

Desferroxamine is used to prevent cardiotoxicity by Doxorubicin

repaglinide&nateglinide stimt Insulin secretion Thiazolidinedione(glitazone)-ci,tro,rosi,pio(PPAR

gamma recp) increses Insulin sensitive

In IR styrene&water used ae refs standerd, Fingerprint region 400-1500percm,Functional grp 1500-4000percm,VitB6 used in pink disease pH of 0.005M HCl ?
SDS PAGE is used for protein seperation. Circular dichromism microscopy is used for optically active compound

Gliclazide is a sulphonylurea that is used as an oral antidiabetic agent.

Clarithromycin is a macrolide that is derived from erythromycin

Azadirachta indica is neem...

Tamoxifen is known hepatocarcinogen... Gallotannin is antioxidant...

practice woodward fisher rule,Beer lambards problems, fragmentation patterns in MS

IR ranges be perfect in above mentioned problems

read clinical trail phases, antidotes.read tables in mohamad ali and piyush COGNOSY-Read Terpenoids and its isoprene units
Basic nucleus of Alkaloidal drugs Types of gums substances and its hydrolytic products

refer insulin nd its preparations,pde inhbitrs,microbial assays,vaccines,diagnostic tests and note

as list of tbls

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tables ( Pharmacrystal rapid Revision Booklet contain all IMP tables for GPAT & NIPER )
draw backs of coating sieve number,mesh size types of ointments size of capsules types of Mills particle size methods

ticlopidine,clopidogrel=thienopyridine derivativs=inhbts platlt agregatn inducd by adenosine

diphosphate

active form of cyclophosphamide is phospharamide mustard and toxic agnt formd is acrolein
causes cystic nephritis

Sennoside A=dextro
Sennoside B=Meso Lieberman Buchnard test for detection of STEROIDS Chenopodium=Ascaridole Papaverine=optically inact

CHOLERA vacine strains-inaba and ogawa, ensyme precursors-zymogens, allopurinol-acute anti gout agnt nd xanthine oxidase inhbtr,ergot od r n Disulfiram like action produced by cefoperazone, mebendazole, metronidazole, procarbazine,
chlorpropamide, nitrofurantoin....

Pellet size ranges from 0.5-1.5 mm.

MCC is d most common diluent to prepare pellets. extrusion spheronization is most common tech to prepar pellet

cyclodextrins are oligpsaccharides produced from starch by CGTase enzyme of Bacillus

macerance.

Read Microbial source & Assay fm IP2007. question may be ask this time in GPAT,read NMR&IR(ranges) frm pavia book. stomata;
coca,senna-paracytic vasaka,peppermint-diacytic eucalyptus,digitalis,lobelia-anomocytic all tropane alkaloid drugs-anisocytic

Morphine is a benzylisoquinoline alkaloid.

morphine acts directly on the central nervous system (CNS) to relieve pain (NSAIDs not act on CNS)

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Denosumab is anti RANK Ligand antibody,do all organ systems from RANG N DALE. Plicamycin(mithramycin) is the only one antibiotic which used in hypercalcemia. Trypnosoma rhodesiense and Trypnosoma gambience cause sleeing seekness. chagas' disease caused by trypnosoma cruzi.. captopril, enalppril, ciclosporin ..this 3 peptide given as oraly..... Amiodaron, Flecainide,Moricizine are used in WPW( Ward -Romano syndrom).. Adenosine used in supraventricular tackycardiya and Magnesium chloride used in digoxin toxicity MYCOPHENOLATE MOEFTIL is ionosine monophosphatedehydrogenase inhibitor.. Everolimus which is mamalion target of Rapamycin(m-TOR)INHIBITOR used in organ transplant
rejection.

HAART tretment;
2 NUCLLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR+ 1 NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OR 1 OR 2 PROTEASE INHIBITOR

OSELTAMIVIR, neuraraminidase inhibitor used in BIRD FLUE....LAMIVUDINE also used

inhepatitis B.pls .

Dulera (mometasone furoate and formoterol fumarate) Inhaler

Treatment for: Asthma...us fda approved..

Raman spectroscopy:
tunable lasers sourc:He-Ni laser DETECTOR: photomultipliers Charge-coupled device detector DETECTION ANGLE:135,90,

Act on microtubules:Thibendazol,Mebendazol,Taxol,Griseofulvin,Vinca
,Colchicine..Hepatotoxic:Na-valproate,paracetamol,halothane..

for measuring viscosity of semisolid like ointment,cream, suspension..creep or oscilatory

viscometer is used.

Main ingred of NAIL POLISH:

Film Former:Nitrocellulose

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Resin:Sulfonamide-Formaldehyde Plasticizer:Dibutyl Pthalate;Colorants:Lake dyes;

In triterpenoid how many isoprene units are present-6

In dipeptide bond how many amino acids are present-3 Wich contain DNA-chromosome

New compound BUCHAPINE used to decrease HIV type1 virus proved by NIPER MOHALI.
Proud to be an Indian

ICH temps:
cold place cool place room temp warm excessive warm 2-8c 8-25c 25c 30-40c >40

Most active enantiomers:

Ephedrine-D(-) Warfarin-S(-) Ibuprofen-S(+) Propranolol-S(levo) Cycloserine-D(+) Ethambutol-Dextro

Imipenem gets rapidly hydrolysed by d enzyme dehydropeptidase I in renal tublr cells.cilastatin is reversible inhibitr of d enzyme.so use in combination.

Montelukast is used for asthma. It will decrease the symptoms and the number of acute asthma
attacks.(new asthma patients only)

Cimetidine have anti androgenic effect(gynecomastia) n cytochrome p-450 inhibitory action also Canrenon is metabolite of Spironolacton n Eplerone is the other Aldosteron antagonist which
have less oestrogen SE

Vit D2-Ergocalciferol
Vit D3- Cholecalciferol 25-OH Vit D3- Calcidiol 1,25 di OH Vit D3- Calcitriiol

kETOCONAZOLE HAVE STREOIODOGENESIS LIKE SIDE EFFECT Pracarbazine, Metronidazole and Sulfonylurea have DISULFIRAM LIKE EFFECT... REFRACTIVE INDEX DETECTOR is also called as BULK PROPERTY DETECTOR...

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RADIO IMMUNO ASSAY is developed by Yellow and Berson in 1959 for assay of insulin...

decapeptide nonapeptide pentapeptide dipeptide

Angiotensin1 , Kallidin Bradikinin , ADH Enkephaline Aspartame

Lithium toxicity caused by..

Ans; Loop diuretics

Oswld ripening is to suspention

GELCAP is cap shaped compressed tab do defintion of gold no Iontophoresis teq deliver chared drug across skin

Cel-O-cal is Direct comression tablet filter.

CaCo3 is also kn s Calcite Cab-O-sil,Aerosil,QUSO e the Silica "pH stat "t i for Evalu f antacid f

coca,hyscomycs,cinchona contain idoiblast calcium oxalate crystals reye"s syn -aspirin

redman syn-vancomycin

the Lyman-alpha forest is the sum of absorption lines arising from the Lyman-alpha transition of
the neutral hydrogen in the spectra of distant gal

Densitometry is the quantitative measurement of optical density in light-sensitive materials, such

as photographic paper or film, due to exposure t

XAS data are obtained by tuning the photon energy using a crystalline monochromator to a range
where core electrons can be excited (0.1-100 keV pho

side effaects:
vancomycin -redman syn

aminoglycosides can cause nephorotoxicity isoniazid=inhibit mycolic acid sys,

rifampacin=DNA dependent RNA polymerase,read MOA all chemotherapy drugs

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shabari: Read % of active constituents in

Ergot,nuxvomica,physostigma,cinchona,ephedra,ipecac,opium. Types of volatile oils

READ SAR of thiazide diuretics, barbiturates, benzodiazepine structure and classification

,antihistamines

READ types of containers used in aerosols

types of Glass types of Preservatives types of surfactants sweetening agents

ScillarinA on enzymatic hydrolysis gives ProscillaridinA, on acid hydrolysis gives ScillaridinA Anthranol dnt giv Borntrager te Turmeric+sulphuric acid=crimson colour
Liquorice+sulphuric acid=yellow colour Reserpine+vanillin =red colour

in mass spctrum,peak with high m/z value=molecular ion peak, peak with high intensity=base peak. HLB value of SLS=40 niper 2010bit. rfr hlb scale,values,formulas,tweens nd spans names ( Pharmacrystal Postal )

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