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to understand their enormous importance in helping us refashion our essentially male models of
normal human function and the pathophysiology of disease. I advocate the use of biological
sex/gender as an important variable in medical investigation; I believe that to do so is to provoke
questions we never would otherwise have asked. Gender-Specific research is crescendoing into a
position of crucial importance in medicine; last month I was invited to address the Special
Interest Group in Women's Health at the NIH. To my great delight, they changed their name to
the Special Interest Group in Gender-Specific Medicine after my visit there. I think my career
has been varied and useful, and although I acknowledge that some of my path has been off the
beaten track, as it were, I think I have been instrumental in pointing out that studying women is
an intellectual imperative, that women's health is more than a political or feminist issue or a
marketing tool for hospitals and that ultimately, women are making men an offer they can't
refuse.
Dr. Legato is the founder and editor of The Journal of Gender Specific
Medicine