In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Tran Q.L., Tezuka Y., Ueda J.-Y., Nguyen N.T., Maruyama Y., Begum K., Kim H.-S., Wataya Y., Tran Q.K., Kadota S.
Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ., 2630 Sugitani, Toyama 930-0194, Japan; Dept. Essential Drugs/Medicines P., World Health Organization, 1211 Geneva 27, Switzerland; Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan; Natl. University - Ho Chi Minh City, Ho Chi Minh City, Viet Nam Abstract: Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquineresistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10g/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5g/ml. Activity-guided fractionation led to identification of berberine as the major active constituent. 2003 Elsevier Science Ireland Ltd. All rights reserved. Author Keywords: Antimalaria; Antiplasmodial; FCR-3; Plasmodium falciparum; Vietnamese medicinal plants Index Keywords: antimalarial agent; artemisia apiacea extract; Artemisia vulgaris extract; Ceiba pentandra extract; Coscinium usitatum extract; Eurycoma longifolia extract; Lasia spinosa extract; Marsilea quadrifolia extract; mimosa pudica extract; Phyllanthus amarus extract; plant extract; polygonum multiflorum extract; Streptocaulon juventas extract; Tinospora cordifolia extract; tinospora crispa extract; unclassified drug; xanthium strumarium extract; antimalarial activity; artemisia apiacea; artemisia vulgaris; article; Ceiba pentandra; concentration response; controlled study; Coscinium usitatum; drug activity; drug identification; drug inhibition; eurycoma longifolia; extraction; fractionation; herbal medicine; Lasia spinosa; malaria; Marsilea quadrifolia; medicinal plant; mimosa pudica; nonhuman; Phyllanthus amarus; Plasmodium falciparum; polygonum multiflorum; Streptocaulon juventas; tinospora cordifolia; tinospora crispa; Viet Nam; xanthium; Animals; Antimalarials; Medicine, Traditional; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Vietnam Year: 2003 Source title: Journal of Ethnopharmacology Volume: 86 Issue: 3-Feb Page : 249-252 Cited by: 27 Link: Scorpus Link Chemicals/CAS: Antimalarials; Plant Extracts Correspondence Address: Kadota, S.; Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ.,

2630 Sugitani, Toyama 930-0194, Japan; email: kadota@ms.toyama-mpu.ac.jp ISSN: 3788741 CODEN: JOETD DOI: 10.1016/S0378-8741(03)00045-X PubMed ID: 12738095 Language of Original Document: English Abbreviated Source Title: Journal of Ethnopharmacology Document Type: Article Source: Scopus Authors with affiliations:
1. 2. 3. 4. 5. 6. 7. 8. 9. Tran, Q.L., Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ., 2630 Sugitani, Toyama 930-0194, Japan Tezuka, Y., Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ., 2630 Sugitani, Toyama 930-0194, Japan Ueda, J.-Y., Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ., 2630 Sugitani, Toyama 930-0194, Japan Nguyen, N.T., Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ., 2630 Sugitani, Toyama 930-0194, Japan Maruyama, Y., Dept. Essential Drugs/Medicines P., World Health Organization, 1211 Geneva 27, Switzerland Begum, K., Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan Kim, H.-S., Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan Wataya, Y., Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan Tran, Q.K., Natl. University - Ho Chi Minh City, Ho Chi Minh City, Viet Nam

10. Kadota, S., Institute of Natural Medicine, Toyama Med./Pharmaceutical Univ., 2630 Sugitani, Toyama 930-0194, Japan

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