PATHOPHYSIOLOGY

HEART KIDNEY Kidney Function

Myocardial O2 Supply Cellular hypoxia Contractility Hyperthtophy Cardiac Output Baroreceptors and Sympathtetic Receptors Stimulates Contractility HR Myocardial O2 Demand MI ESRD Damage to the Glomeruli

Unable to Excrete Metabolic waste Fluid Retention

EDEMA

DEATH

Pulmonary Congestion

PATHOPHYSIOLOGY
MODIFIABLE FACTORS NON MODIFIABLE FACTORS Obesity Hypertension Diabetes Sedentary Lifestyle Heart Failure Nephrotic Syndrome Old Age Male Race

Decreased Blood Flow in the Renal Arteries

Release of renin by juxtaglumerular Enters the Bloodstream Angiotensinogen in the liver to angiotensin I ACE converts angiotensin I to angiotensin II

Vasoconstriction

Release of Aldosterone Sodium Retention Increase Plasma

BP

Tissue Perfusion

Oxygen Supply