Beruflich Dokumente
Kultur Dokumente
Goals:
By the end of this lecture, you should be able to:
• Describe the key pros/cons of different materials
• Describe different mechanical tests & interpret data
• Describe differences between metals, ceramics, polymers
• Identify condensation & addition polymerization reactions
• Define thermoset & thermoplastic polymers
• Calculate average molecular weight of a polymer
• Calculate degree of polymerization for a polymer
• Discuss the properties that affect polymer degradation
• Describe different polymers processing techniques
Outline:
I. Introduction & General Classification of Materials
II. Analysis of Material Properties
III. Polymer Basics
A. Classification
B. Polymerization Reactions
C. Copolymers
IV. Polymer Properties
A. Desired Polymer Properties
B. Thermoset & Thermoplastic Behavior
C. Elastomer Behavior
D. Hydrogels
V. Polymer Degradation & Biodegradable Polymers
VI. Polymers Processing for Tissue Engineering
BME 379/385, CHE 379: Biomaterials I -- 2
• Ceramics
• Polymers
• Composites
BME 379/385, CHE 379: Biomaterials I -- 3
Metals:
Titanium
Gold
Ceramics:
Hydroxy apatite
Pyrolytic carbon
LTI pyrolytic carbon
BME 379/385, CHE 379: Biomaterials I -- 4
Polymers:
Natural polymers
Biomechanics
A common property measured of most materials is tensile strength:
2 3
B
1
Stress A
Strain
To construct this tensile stress-strain plot, a rod or "dog-bone"
shaped material specimen is stretched using a mechanical test
machine (instron). Force (Newtons) is applied to the specimen, and
deformation of the specimen is measured (mm). Stress, σ (N/m2 or
Pascals), is calculated as force divided by the original cross-sectional
area. Strain, ε (%), is calculated as the change in length divided by
the original length.
Example Problem: You are to design a cable that must support an elevator cab that
weighs 10,000 lb. The cable is made from the aluminum alloy, whose data is presented in
the figure below. Calculate the minimum diameter of the cable required to support the
cab without permanent deformation.
Expanded View
Stress-Strain for Alluminum Alloy
40000
45,000
35000
40,000
35,000 30000
30,000 25000
Stress (psi)
Stress (psi)
25,000
20000
20,000
15000
15,000
10000
10,000
5,000 5000
0 0
0.00 0.02 0.04 0.06 0.08 0.10 0.12 0 0.001 0.002 0.003 0.004
Strain (in/in) Strain (in/in)
Stress
Strain
A ductile material?
BME 379/385, CHE 379: Biomaterials I -- 8
Fatigue Wear
BME 379/385, CHE 379: Biomaterials I -- 9
A. Classification
1. Polymerization mechanism
Condensation polymerization
Addition (free radical) polymerization
2. Polymer structure
Linear
A' (A)X-2 A"
Branched
A' (A)n Y (A)n Y
(A)n (A)n
Crosslinked (networks)
3. Polymer behavior
Thermoplastic –
Thermosetting –
BME 379/385, CHE 379: Biomaterials I -- 11
B. Polymerization Reactions
1. Condensation Polymerization
R-NH2 + R'COOH --> R'CONHR + H20
(amine) (carboxylic acid) (amide)
This free radical can then react with another monomer in a process
called propagation:
R• + M --> RM•
RM• + M --> RMM•
Polydispersity:
M w ∑ (Wi • MWi)/∑ Wi
=
M n ∑ (Xi• MWi)/∑ Xi
C. Copolymers
Definition:
Types of copolymers:
--AABBABAABBBABAABAAABBABA—
--ABABABABABABABABABABABAB—
--AAAAAA--BBBBBB--AAAAAA--BBBBBB—
--AAAAAA--AAAAAA--AAAAAA--
B B B
B B B
B B B
BME 379/385, CHE 379: Biomaterials I -- 14
Thermoplastic Behavior:
C. Elastomer Behavior
D. Hydrogels
Definition:
There are several biodegradable polymers that already exist and that
are being developed for tissue engineering applications. Two of the
more common biodegradable polymers are PGA and PLA. These
materials are commercially available and are already FDA-approved
for surgical procedures (e.g., biodegradable sutures).
Polyesters:
Polyglycolic Acid (PGA)
H O H O
O C C O C C O
H H
These degradation products, although natural to the body, are acidic -- too fast
of a degradation rate can be detrimental to cells (pH ).
Phase separation
Laser
XYZ CAD
Controller Station
Beam
Shutter
Lens
Platform
Chemical/Biomolecule Modification