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NURS 1566 Clinical Form 3: Clinical Medications Worksheets

(You will need to make additional copies of these forms)

Generic Name Trade Name Classification Dose Route Time/frequency


clopidogrel Plavix antiplatelet agents 75 mg PO daily
Peak Onset Duration Normal dosage range
3-7 days Within 24 hr 5 days 75mg once daily

Why is your patient getting this medication For IV meds, compatibility with IV drips and/or solutions
Reduction of atherosclerotic events (stroke) N/A

Mechanism of action and indications Nursing Implications (what to focus on)


(Why med ordered) Contraindications/warnings/interactions
Inhibits platelet aggregation by irreversibly inhibiting the binding Hypersensitivity, pathologic bleeding (peptic ulcer, intracranial
of ATP to platelet receptors. The active metabolite of clopidogrel hemorrhage), patients at risk for bleeding (trauma, surgery, or other
prevents binding of adenosine diphosphate (ADP) to its platelet pathologic conditions), history of GI bleeding/ulcer disease.
receptor, impairing the ADP-mediated activation of the Common side effects
glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition GI BLEEDING, BLEEDING, NEUTROPENIA, THROMBOTIC
involves a defect in the mobilization from the storage sites of the THROMBOCYTPENIC PURPURA
platelet granules to the outer membrane. No direct interference
occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa
complex is the major receptor for fibrinogen, its impaired
activation prevents fibrinogen binding to platelets and inhibits
platelet aggregation. By blocking the amplification of platelet
activation by released ADP, platelet aggregation induced by
agonists other than ADP is also inhibited by the active metabolite
of clopidogrel.
Interactions with other patient drugs, OTC or herbal medicines Lab value alterations caused by medicine
(ask patient specifically) Monitor bleeding time during therapy. Prolonged bleeding time,
Increased bleeding risk with anise, arnica, chamomile, clove, which is time- and dose-dependent, is expected
fenugreek, feverfew, garlic, ginger, ginkgo, panax genseng, and Monitor CBC with differential and platelet count periodically
others. ASA may increase risk of bleeding. during therapy. Neutropenia and thrombocytopenia may rarely
occur. May cause inc. serum bilirubin, hepatic enzymes, total
cholesterol, nonprotein nitrogen (NPN), and uric acid
concentrations.
Be sure to teach the patient the following about this medication
Avoid taking OTC medications containing aspirin or NSAIDs
without consulting health care professional.

Nursing Process- Assessment Assessment Evaluation


(Pre-administration assessment) Why would you hold or not give this med? Check after giving
History and physical, assess risk for blood clots. Fever, chills, sore throat, or unusual bleeding Successful prevention of stroke.
or bruising occurs.

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