Mitosis

What

is it? Why is it Important?

What

do I need to know?

Why more cells?

Populations of single-cell critters Multicellularity? We all start out as a single cell? The zygote & become/remain multicellular

Binary FissionMonera

Binary Fission..DNA duplicateswhy?

DNA separates & new cell wall divides cell in two

2 new cellsidentical?

Binary Fission

quiz
What happens to the size of bacteria after binary fission? What has to happen before fission occurs? What benefit(s) do bacteria derive from binary fission (as opposed to sexual reproduction)?

Eukaryotic cells??

The nucleus? Nuclear membrane Chromosomesnot chromosome? All that stuff in the cytoplasm?

Eukaryotic cell cycle

Cell is born Duplicates DNA?? Grows tosize? Prepares to divide Divides=mitosis

Control of mitosis:CYCLIN

The nuclelus must first divide before the cell can

Why? How? How much time of the cell cycle/life can be spent in mitosis?

Chromosomes duplicate

Kinetochore (centromere)

Mitosis produces identical offspring (2N---2N)

Why some cells stop mitosisdifferentiation

Muscle cells Nerve cells Critical functions might be disrupted Adaptations to this condition

Importance???

Growth Replacement Cancer Regeneration of

Cancer?

Unregulated mitosis Benign Malignant/ metastasis How does it begin?

Normal cycle controls

Internal signals External signals: growth factors fibronectin,etc carcinogens Apoptosis Immune functions And

Cell immortilization!!

Hayflick limit?? Hela cells Contact inhibition Increased telomerase activity = immortalization!

Immortalization???

If you replaced Why not??look at your shoestrings? Telomerase & telomeres & ? Recently Implications???

Mitosis quiz

Use two words to describe the importance of mitosis Draw and label the cell cycleinclude G1, S, G2, M and cytokinesiswhat happens at each stage? Why might telomerase be important? What disease is associated with mitosis? Are all organisms limited to 50 mitotic divisions?

Name stage of mitosis

Name stage of mitosis

Name stage of mitosis

Name stage of mitosis

Name stage of mitosis

Name stage of mitosis

Name stage of mitosis

Name stage of mitosis

These are bacteria

Watch the clip What kind of reproduction is shown here? What advantage does this confer on the organism?