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Metabolic Diseases:
Post part. Hypo-phosphatemia
Post-parturient Hemoglobinuria,
by
Dr. Ali H. Sadiek
Prof. of Internal Veterinary Medicine
and Clinical Laboratory Diagnosis
Faculty of Veterinary Medicine, Assiut University
E-mail: Sadiek59@yahoo.com
Post part. Hypo-phosphatemia
Post-parturient Hemoglobinuria,
Puerperal Hemoglobinburia
• Affect high lact. cows 2-6 weeks after part.
• May affect buff. cows before or after part.
• It is widely distributed in Egypt esp. in winter.
• Charct. clinically by hemolysis of RBCs,
Hemoglobonuria, anemia and loss of condition.
Causes:
• Not really understood, but severe
drop in serum P levels a result of
its secretion in milk and intensive
milk production may predispose to
the condition.
• Heavy feeding on hemolytic or
oxidative plant toxins (e.g Brassica
spp , sugar beets, or green forage)
and plants low in P (cruciferous
plants & Barseem) may predispose
to the case.
Phosphorus is essential for:
1- Intracellular functions e.g:
• Glycolysis,
• Oxygen transport,
• Muscle contraction.
• Protection of cell memb. from oxidative
damage.
2-It is an important component of:
Bones, milk, and ruminant saliva.
3- P deficiency is usually primary and
results in organ and system dysfunction
and finally progressive demineralization
of bone.
Suggested Pathogenesis of PPHburia
Heavy -1 Oxidative plant -2 3- Cruciferous plant
lactation (toxins (brassica, Sugar beets (Low P & saponin)
Cu , Se deficiency-4
Hypophosphatemia
Hemolysis of RBCs
Hemoglobinurea
Cystitis Leptospirosis
Acute pyelonephritis Water or salt poisoning