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Tutorials 1: Jpn J Cancer Res. 1985 Dec;76(12):1174-8. Related Articles, Links

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E-Utilities Evaluation of vitamin A and C status in normal and malignant conditions and their possible
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role in cancer prevention.
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MeSH Database Ghosh J, Das S.
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Clinical Queries A comparative study has been made on the levels of vitamins A and C in normal and malignant conditions in
Special Queries human and murine subjects. Further, the effect of supplemental vitamins A and C on tumor take,
LinkOut host-survival and tumor growth have been studied in a number of transplantable and induced tumors in mice.
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The vitamins were assayed in sera samples from normal subjects, patients with cancer of the uterine cervix or
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ovary, and leukemia and lymphoma patients. Among the murine group the tumors included sarcoma 180 in
Order Documents solid and ascitic form, benzo[a]pyrene-induced fibrosarcoma, Dalton's ascitic lymphoma and Schwartz
NLM Mobile lymphoblastic leukemia. The serum level of vitamin C was found to be lower than that of the normal controls
NLM Catalog in all cases studied. The level of vitamin A was found to be higher in cancer patients in the human group and
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TOXNET lower in the murine group when compared with their normal controls. Studies on murine tumors showed that
Consumer Health supplementary vitamins administered at the initial phase of tumor development reduced the percentage
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ClinicalTrials.gov tumor take and the rate of tumor growth, and improved host survival, indicating that these vitamins have a
PubMed Central protective role in the murine system.

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PMID: 3937831 [PubMed - indexed for MEDLINE]

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