CYP 1A2

INHIBITOR Cimetidine (weak) Ciprofloxacine (mod) Fluvoxamine (strong) Verapamil (weak) SUBSTRATE Agomelatine Amitriptyline Clozapine Duloxetine Fluvoxamine Haloperidol Imipramine Paracetamol Propranolol Theophylline Warfarin zolmitriptan INDUCER Omeprazole Phenobarbitone Phenytoin Tobacco smoking

CYP 2B6
INHIBITOR Clopidogrel SUBSTRATE Clopidogrel Cyclophosphamide methadone INDUCER Phenobarbitone Phenytoin rifampicin

CYP 2C8
INHIBITOR Gemfibrozil (strong) trimethoprim SUBSTRATE Pioglitazone Repaglinide rosiglitazone INDUCER rifampicin

CYP 2C9
INHIBITOR Amiodarone (mod) Fluconazole(mod) Fluoxetine Fluvoxamine voriconazole SUBSTRATE Amitryptiline Celecoxib Fluoxetine Fluvastatin Glibenclamide, gliclazide, glimepiride, glipizide Ibuprofen Phenytoin Rosiglitazone, rosuvastatin Tamoxifen Warfarin (s isomer) INDUCER Rifampicin St johns wort

CYP 2C19
INHIBITOR Cimetidine Clarithromycin Fluoxetine Fluvoxamine Omeprazole (strong) Oxcarbazepine Topiramate voriconazole SUBSTRATE Amitriptiline Clopidogrel Diazepam Imipramine Lansoprazole Omeprazole Pantoprazole Phenobarbitone Phenytoin Propranolol Warfarin r isomer INDUCER Carbamazepine Rifampicin St johns wort

CYP 2D6
INHIBITOR Amiodarone (weak) Celecoxib Cimetidine Cinacalcet Duloxetine (mod) Fluoxetine (strong) Paroxetine (strong) Methadone Terbinafine (mod) SUBSTRATE Amitryptiline Aripiprazole Atomoxetine Carvedilol Chlorpromazine Cinacalcet Clozapine Codeine Dextromethorphan Donepezil Duloxetine Flecainide Fluoxetine Fluvoxamine Galantamine Haloperidol Imipramine Metoclopromide Metoprolol Nortryptiline Olanzapine Paroxetine Perhexiline Propranolol Risperidone Tramadol venlafaxine INDUCER

CYP 3A4
INHIBITOR Cimetidine (weak) Clarithromycin (strong) Diltiazem (mod) Erythromycin (mod) Fluconazole (mod) Fluvoxamine Grapefruit juice (mod) Itraconazole(strong) Ketoconazole(strong) Posaconazole Verapamil (mod) SUBSTRATE Amiodarone Amitriptyline Aripiprazole Atorvastatin Carbamazepine Cinacalcet Clarithromycin Cocaine Codeine Colchicines Cyclosporine Dexamethasone Diazepam Diltiazem Donepezil Eplerenone Ethinylestradiol Felodipine Fentanyl Fluvastatin Galantamine Haloperidol Hydrocortisone Imipramine Methylprednisolone Midazolam Mirtazapine Nifedipine Omeprazole Propranolol Quetiapine Reboxetine, repaglinide, risperidone, rivaroxaban Simvastatin Tramadol Venlafaxine, verapamil, vinblastine, vincristine Warfarin r isomer zolpidem INDUCER Carbamazepine Corticosteroid Modafinil Phenobarbitone Phenytoin Rifampicin St johns wort