Patofisiologi dementia

Primary degeneration aetology (Alz,pickD)

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Ischaemic aetiology

Stroke, multi-infr D

Metabolic aetiology (intoxication, hypoxia, Circulation colaps

Distrub regulation of DNA Trancription (distrubed template activity)

Quality exhaution of Neuronal reserve capacity For CNS performance

Decreased glycolitic turn over

Distrubed enrgy supply through decreased

Recuperative capacity of CNS metabolisme

Decreased AC-Coa Synthetic Decreased Acetylchlone synthesis

DEMENTIA

MIchondria

Dysfunction Ca** homeostasis

Plasma choles APP & Presenilin APOEe4 mutation

Aging

AB

Oxidative stress apoptosis synaptic damage NT deficit Neuron degeneration neuronal death DEMENTIA

production

Tau protein hyperphosphorilation