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Roll No.

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TotalNo.of Questions : 101 [TotalNo.of PrintedPaEes: 4

PHM-3.5.1
PHARMACEUTICAL CHEMISTRY-V

(Biochemistry)
(B.Pharmacy, sth Semester, 21231
Time: 3 Hours Maximum Marks: 80

Note:-This paper consists of ThreeSections. Section A is compulsory. Attemptany Fourquestions fromSection B and any Three questions from Section C.
Section-A 1. Marks:2 Each

(a) Fromwheredoesenergyrequired to lower activationenergy in enzyme catalysed reaction comes? PHM-3.5.1

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(2) (b) Whatis the difference betweenhomotropic and heterotropic allosteric enzymes? (c) Whichenzymecatalyse the rearrangement of L-methylmalonyl-CoA to succinyl-CoA ? Namethe co-enzyme involved. (d) Givethe biotogical significance of GLUT. (e) Whatare the causesand characteristics of Cori'sdisease? (f) Whatare the characteristics and causesof Tarni's disease? (g) i How does fluoroacetate act as poison?
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6)

What do you mean by pCR and point mutation ?

(i)

What do you mean by prochiral __ compounds ? Explain with examples.

(j)

What is the roleof Acetyl-CoA carboxylase in regulation of Lipogenesis ? PHM-3.5.1

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(3) (k) What is the cause of Jamaicanvomiting sickness? (l) Explain the termsureotelic, uricotelic and ammonatelic. \(m) Explainthe terms fingerprintingand foot printing. (n) Givethe structure of Cholecalciferol. (o) Name different processes involved in solutemigration acrosscell membrane. Section-B 2. Marks:5Each

write a note on kineticsof enzyme catalyzed reactions.

3. 4. ,5.

Writea note on biosynthesis of aminoacids. Writea short noteon citricacidcycle. E x p l a i nw i t h s t r u c t u r e st h e i n t r a m o r e c u r a r rearrangement i n v o l v e d i n c o n v e r s i o no f L-methylmalonyl-CoA to succinyl CoA. Writea shortnoteon Fermentatiqn. toy PHM-3.5.1 TurnOver

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(4) Section-C 7. 8. Marks: 10 Each

Writea note on Fattyacid oxidatio n./ Writea noteon purinenucleotide biosynthesis. Explainhow glutamine analogsblockit. \-

9.

What is the fate of glucosein the body ?/

10. Differentiate between: (a) Cystinuria, . Cystinosis and

Homocystinurias (b) Tyrosinosis, Tyrosinemia and Alkaptonuria.

PHM-3.5.1

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