Total No.

of Questions : 8]

[Total No. of Printed Pages : 3

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First Year B. Pharm. Examination - 2009
PHARMACEUTICAL CHEMISTRY - II (Organic) (2004 Course) Time : 3 Hours] Instructions : (1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt two questions each from Section I and Section II. (2) Answers to the two sections should be written in separate answer-books. (3) Black figures to the right indicate full marks. [Max. Marks : 80

SECTION - I
Q.1) (A) Define any four of the following : (a) (b) (c) (d) (e) Tautomerism Carbene Enantiomerism Resonance Electrophile [04]

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P.T.O.

(B)

Give IUPAC Nomenclature of any four of the following : (a) C6H5 SO3H CH3 CH3 CH2 CH CH2 OH CH3 CH3 N CH CH2 CH3 CH3 C6H5 CH2 CHO CH3CH2 OCH2CH3

[04]

(b) (c) (d) (e) (C)

What do you mean by Structural Isomerism ?

[02] [15]

Q.2) Give reasons : (Any Four) (a) (b) (c) (d) (e) (f) Q.3) (A) (B) (C) N, N, Dimethyl Aniline is a stronger base than Aniline. P-nitrophenol is a stronger acid than Phenol. Electron donating groups are O, P directors in electrophilic aromatic substitution. Trifluoroacetic Acid is a stronger acid than Trichloroacetic Acid. Meso compounds do not show optical activity. Cis and trans isomers differ in their melting and boiling points. Explain SN1 reaction. Explain SN2 reaction. Explain Friedal Craft Acylation

[05] [05] [05] [15]

Q.4) Write short notes : (Any Three) (a) (b) (c) (d) [3656]-14 Geometrical Isomerism SNi Reaction Reaction Intermediates Transition State Theory 2

Contd.

SECTION II
Q.5) What are Elimination Reactions ? Explain mechanism of E1 and E2 reactions and factors affecting elimination reactions. [10] Q.6) (A) (B) Q.7) (A) (B) (C) Explain addition reactions of Halogens and Halogen Acid to Olefins. [08] Explain addition reactions to Aldehydes. Explain methods of Separation of Amines Mixture. Explain reactions of Carboxylic Acids. Explain reactions of Amines. [07] [05] [05] [05] [15]

Q.8) Write short notes : (Any Five) (a) (b) (c) (d) (e) (f) Hydrogenation of Olefins Knoevengel Condensation Elcb Reaction Saytzeffs Rule Basicity of Amines Aldol Condensation

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