Beruflich Dokumente
Kultur Dokumente
OH
Paracetamol is both an analgesic and an antipyretic. Unlike aspirin and ibuprofen, paracetamol has no anti-inflammatory properties. Paracetamol is toxic to the liver and consequently high doses can be fatal:
CH3
Acute poisoning 10g in a single dose. Chronic poisoning 5g every 24 hours for a prolonged period of time.
C O
Paracetamol
+
H
Cl Cl
AlCl3 H
C C
C C H
C C
+
H
H Cl
Chlorobenzene
+
H
NaOH
Reflux H
C C
C C H
C C
+
H
NaCl
Phenol
H Phenol
NO2 4-Nitrophenol
NO2 4-Nitrophenol
H H 4-Aminophenol
+
H
H3C C Cl
H Cl
N H H 4-Aminophenol
O Paracetamol
Question:
If each step in the synthesis of paracetamol gives a yield of 80%, what mass of paracetamol will be synthesised from 1.0 kg of benzene?
H3C
C O
OH
Ibuprofen is classified as a non-steroidal anti-inflammatory drug (abbreviated to NSAID). Ibuprofen is mostly used to treat pain resulting from inflammation, e.g. rheumatism. The side-effects of ibuprofen are far less significant than those of other NSAID compounds such as aspirin.
Ibuprofen
H H H C C C C H C C H
+
H
H H H H C H H C C C Cl H H H
H H H H C C C H H H C H H AlCl3 H H C C C C H C C H H
H Cl
H H H H C C C H H H C H H H H C C C C H C C H H
H C C H
C C C H
C C C
C C O
+
H
H Cl
H H H C C C H H H C H H H H H H C C C H C C C C C O H H
H C OH H H
H C OH H H
H C Br H H
+
H
KC N H
C C
C C C H
C C
+
H
KBr
H C Br H H
H C C N H H
H H H H C C C H H H C H H H C C C C C H C C H H
H C C N H H
H C COOH H H
Ibuprofen