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MODS is progressive impairment of two or more organ system. This is the result of an uncontrolled inflammatory response to severe injury or illness. It is the another phase in the
CLASSIFICATIONS OF MODS
Primary MODS is the result of direct tissue insult, which then leads to impaired perfusion or ischemia. Secondary MODS is most often a complication of septic shock or SIRS.
CaUSES:
Dead or injured tissue Infection Perfusion deficits For acutely ill patients advanced age , malnutrition and coexisting diseases increase the risk of MODS.
Gut hypothesis:
The most popular hypothesis to explain MODS in critically ill patients is the gut hypothesis. Due to: splanchnic hypoperfusion subsequent mucosal ischaemia there occurs structural changes and alterations in cellular function. This results in increased gut permeability, changed immune function of the gut and increased translocation of bacteria. Hepatic dysfunction leads to toxins escaping into the systemic circulation and activating an immune response. This results in tissue injury and organ dysfunction.
Integrated hypothesis
Since in most cases no primary cause is found, the condition could be part of a compromised homeostasis involving the previous mechanisms.