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A change in the nucleotide base sequence of the DNA or a change in the structure or number of chromosomes
Mutagens
Mutagens cause mutations which are mistakes in the base sequence of the DNA. (If you change the recipe, you change the cake)
There are two types: Point mutations and chromosomal mutations Point Mutations involve changing a single nucleotide base. There are 3 types:
1. Substitution mutations involve replacing one base with another. Like a sports team
TAC ACC GTA TTC CAT TCC TAC ACC GTG TTC CAT TCC (old DNA) (new DNA)
This may or may not change the product being made, depending on where it occurs. If it is in the last position of a triplet, then not so bad, if it is in the first or second, then it probably will change.
Chromosomal mutations
Having an extra chromosome or one too few Sometimes, chromosomes fail to separate during 1st or 2nd stages of meiosis This means that one gamete (sex cell eg sperm or egg) may be missing a chromosome OR The others will have an extra chromosome and, when fertilised, will have three copies trisomy Examples are: downs syndrome, kleinfelters syndrome
Downs syndrome