Imunogenetik

dr. NI Made Mertaniasih

1. Internalization by endocytosis into endosomes

5.Presentation of peptide MHC complex to CD4+ T cell

4. Fusion of endosome with plasma membrane expression of peptide MHC complexes on cell surface

2.Processing of protein in endosome generating immunogenic peptides

Vesicle containing class II MHC molecules

3a. Fusion of endosome with vesicle bearing class II MHC molecules

3b. Binding of immunodominant peptide to class II MHC molekules

Further degradation of unbound Peptides to amino acids