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PATHOPHYSIOLOGY OF MENIERES DISEASE

Etiology: IDIOPATHIC

Predisposing Factors: AUTOIMMUNITY GENETIC SUSCEPTIBILITY

Precipitating Factors: ALLERGY METABOLIC DISTURBANCES VIRAL ILLNESS

Inflammation

Increase production and Decrease excretion of endolymph

Increase in endolymphatic pressure

Physical Distention

Mechanical Disturbance of the Organ of Corti

Tx: Diuretic (Water Pill) Betahistine Dexamethasone

Breakage in Reissners membrane Mixture of Perilymph and Endolymph Bathe the vestibular nerve receptors Repolarization blockade

Distortion of the Basilar membrane, inner and outer hair cells

Distortion of the Cochlea (Apex part)

Tinnitus

Low frequency Hearing Loss

Change in the rate of vestibular nerve firing Vertigo

Tx: Caroverine

Tx: Hearing Aid

Surgery: Labyrinthectomy

Surgery: Vestibular nerve section

Tx: Meclizine Prochlorperazine Gentamicin Diazepam

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