Department Seminar

Jared L. Anderson
Department of Chemistry, The University of Toledo, Toledo OH 43606 USA Exploiting the Versatility of Ionic Liquids in Sample Preparation, Multidimensional Chromatography, and Pharmaceutical Analysis A. Vitae
Ionic liquids (ILs) are a unique class of non-molecular solvents whose versatility allows them to be incorporated into various aspects of chemical analysis. ILs possess negligible vapor pressures at room temperature, have a wide range of viscosities, can be custom-synthesized to be miscible or immiscible with water and organic solvents, often have high thermal stability, and are capable of undergoing multiple solvation interactions with many types of molecules. In addition, ILs can be structurally tuned to modulate desired physio-chemical properties while retaining their unique solvation capabilities. This talk will discuss the use of ILs in sample preparation, chromatographic separations, and pharmaceutical analysis. The use of ILs and polymeric ionic liquids (PILs) will be described for improving the selectivity, sensitivity, and reproducibility when used as sorbent coatings in solid-phase microextraction (SPME) and as extraction solvents in dispersive liquid-liquid microextraction (DLLME). Secondly, it will shown that the unique cation/anion combination of ILs gives rise to unique chromatographic selectivity when IL-based stationary phases are employed as the second dimension column in comprehensive multidimensional gas chromatography (GC GC). Finally, the structural tuneability of ILs make them particularly attractive solvents for the analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (API). GTIs are a category of compounds that are highly regulated in the pharmaceutical industry due to their DNA mutagenic effects. New guidelines imposed by the United States Food and Drug Administration have lowered the permissible amounts of these compounds in APIs and has generated the need for new analytical methods to aid in their determination. This talk will discuss new approaches designed in our lab aimed to achieve high GTI enrichment factors while allowing the method to used towards a wide array of structurally diverse pharmaceutically-relevant molecules.

Wednesday, December 4, 2013 SAV 378 12:00-1:00 p.m.