Method Validation Course Day 1 Essential statistics

09:00 09:30 09:40 10:00 10:50 11:10 11:30 12:05 12:20 13:20 14:00 14:35 Registration and coffee Introduction Introduction to statistics: Description of data Workshop A1: Calculation of statistical parameters Coffee Significance testing: t-tests Workshop A2: Significance testing, t -tests Significance testing: The F-test Lunch Workshop A3: Significance testing, the F-test Analysis of Variance Workshop A4: ANOVA, types of hypotheses, interpretation of results Tea Linear regression: Part 1. Interpretation of parameters and pitfalls Workshop A5: Linear regression (I) Linear regression: Part 2. Workshop A6: Linear regression (II) Close and round up of Day 1

15:15 15:35 15:50 16:05 16:30 17:20

2003 LGC Limited

Method Validation Course Day 2 Providing the tools

09:00 09:45 10:15 10:35 Introduction to method validation Workshop B1: Building a validation protocol Coffee Performance parameter 1: Precision, different precision parameters, description and how each is estimated Workshop B2: Interpreting precision data Lunch Performance parameter 2: Bias , experiments for estimation, tests for bias Workshop B3: Interpreting data on bias Tea Performance parameter 3: Ruggedness, experiments to evaluate ruggedness Workshop B4: Designing and interpreting ruggedness tests Review of Day 2 Close

11:15 12:20 13:20 13:45 15:00 15:20

15:40 16:40 16:45

2003 LGC Limited

Method Validation Course Day 3 Further tools

09:30 Recap of Day 2 Performance parameters 4: Selectivity, LoD and LoQ Workshop C1: Examples illustrating lack of selectivity, how to evaluate LoD and LoQ Coffee Performance parameters 5: Linearity and working range Workshop C2: Interpreting linearity and range data Lunch Measurement uncertainty: Estimations using validation data Workshop C3: Evaluating measurement uncertainty Tea Workshop C4: Revision and completing the validation protocol Review of course Close

10:00

10:45 11:05 11:25 12:30 13:30 14:00 15:00 15:20 16:20 16:30

All timings are approximate

2003 LGC Limited