waktu sampling

kadar(jam)
furosemid (mg/L)
t
c
ln c
0.25
0.2 -1.60944
0.5
1.9 0.641854
1
5.4 1.686399
1.5
7.5 2.014903
3
7.1 1.960095
4
6.7 1.902108
6
5.8 1.757858
8
5.1 1.629241
10
4.5 1.504077
12
4.1 1.410987 a=
16
3.5 1.252763 b=
24
2.4 0.875469 r=

ln c'
1.942832
1.931652
1.909291

1.954013
-0.04472 k=
-0.99939

c'
6.978489
6.900901
6.748303

cr
6.778489
5.000901
1.348303

ln cr
1.913754
1.609618
0.298847

0.044722

8
7
6
5
4
3
2
1
0
0

10

15

20

25

neg ka=

t1/2
vd
cl

-2.22011

2.5
2
1.5
1
0.5
y = -2.2201x + 2.5691
R = 0.9761
0
0
5
Series1

25

30

y = -0.0447x + 1.954
R = 0.9988

10

15

20

25

30

Series1
eliminasi
absorbsi
Linear (eliminasi)
Linear (eliminasi)
Linear (absorbsi)

waktu sampling
kadar(jam)
furosemid (mg/L)
t
c
ln c
0.25
0.13
0.5
2.1
1
5.4
1.5
7.5
3
7.1
4
6.5
6
5.8
8
5.1
10
4.5 1.504077
12
3.9 1.360977 a=
16
3.5 1.252763 b=
24
2.1 0.741937 r=

ln c'
c'
cr
2.024249 7.570421 7.440421
2.010981 7.470645 5.370645
1.984447 7.27502 1.87502

2.037516
-0.05307 k=
-0.99055

ln cr
2.006927
1.680948
0.628619

0.05307

8
7
6
5
4
3
2
1
0
0

10

15

20

25

neg ka=

-1.87587

t1/2
vd
cl

Series1

25

30

t
0
0.25
0.5
1
1.5
3
4
6
8
10
12
16
24
tak hingga

ln c
0
0.2
1.9
5.4
7.5
7.1
6.5
5.8
5.1
4.5
4.1
3.5
2.1
0

1.504077
1.410987 a=
1.252763 b=
0.741937 r=

AUC n-1 spAUC

n 0 sp n
0
0
0.025
0.025
0.2625
0.2875
1.825
2.1125
3.225
5.3375
10.95 16.2875
6.8 23.0875
12.3 35.3875
10.9 46.2875
9.6 55.8875
2.073611
8.6 64.4875
-0.05459
15.2 79.6875
-0.99444
22.4 102.0875
38.46747 140.555

0
0.001365
0.015695
0.115325
0.291383
0.88916
1.260383
1.931859
2.526908
3.050987
3.520474
4.350266
5.573117
7.673117

0
0.201365
1.915695
5.515325
7.791383
7.98916
7.760383
7.731859
7.626908
7.550987
7.620474
7.850266
7.673117
7.673117

0
1
0.026243 0.973757
0.249663 0.750337
0.718785 0.281215
1.015413
1.041188
1.011373
1.007656
0.993978
0.984083
0.993139
1.023087
1
1

0
-0.02659
-0.28723 b=
-1.26864

tmaks
cpmax
auc

-0.24506 ka=

0.24506

t
0
0.25
0.5
1
1.5
3
4
6
8
10
12
16
24
tak hingga

c
0
0.2
1.9
5.4
7.5
7.1
6.7
5.8
5.1
4.5
4.1
3.5
2.4
0

ln C

[AUC]tn-1 s/d t
0
0.025
0.2625
1.825
3.225
10.95
6.9
12.5
10.9
-0.04472
1.504077 b=
9.6
1.410987 k= 0.044722
8.6
jam-1
1.252763
15.2
0.875469
23.6
#NUM!
53.66502635

[AUC] 0 s/d n
0
0.025
0.2875
2.1125
5.3375
16.2875
23.1875
35.6875
46.5875
56.1875
64.7875
79.9875
103.5875
157.2525264

k [AUC]0 s/d n
0
0.001118047
0.012857536
0.094474937
0.238702948
0.728407357
1.036988217
1.596011515
2.08347983
2.512809723
2.897417752
3.577190082
4.632626068
7.032626068

Ab/Vd
0
0.201118047
1.912857536
5.494474937
7.738702948
7.828407357
7.736988217
7.396011515
7.18347983
7.012809723
6.997417752
7.077190082
7.032626068
7.032626068

7
6
5
4

Series1

3
2
1
0
0

10

15

20

25

30

Ab/Ab tak hgga

(1-Ab/Ab tak hgga)

Ln (

0.028597859
0.271997618
0.781283533
1.100400174

0.971402141
0.728002382
0.218716467

-0.029014745
-0.317450958
-1.519979057

b=
ka=

-2.04754
2.047539
jam -1

t maks= 1.909277