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Glimepiride (cas 93479-97-1) MSDS

:
1H-Pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyc

MSDS

lohexyl)amino) carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-

CAS SYNONYMS

: :

93479-97-1 * Glimepirid * Glimepiride * HOE 490

Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers [ 1H-Pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans- 93479-97-1 ]

*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER CHEMICAL NAME

: UX9363950 : 1H-Pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyc lohexyl)amino) carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-

CAS REGISTRY NUMBER

: 93479-97-1

BEILSTEIN REFERENCE NO. : 5365754 LAST UPDATED DATA ITEMS CITED MOLECULAR FORMULA MOLECULAR WEIGHT COMPOUND DESCRIPTOR : 199612 : 5 : C24-H34-N4-O5-S : 490.68 : Drug Reproductive Effector SYNONYMS/TRADE NAMES : * Glimepirid * Glimepiride * HOE 490

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST ROUTE OF EXPOSURE SPECIES OBSERVED DOSE/DURATION TOXIC EFFECTS :

: LD - Lethal dose : Oral : Rodent - rat : >10 gm/kg

liver - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1Volume(issue)/page/year: 43,547,1993 1951-

TYPE OF TEST ROUTE OF EXPOSURE SPECIES OBSERVED DOSE/DURATION TOXIC EFFECTS :

: LD - Lethal dose : Intraperitoneal : Rodent - rat : >3950 mg/kg

Liver - other changes REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1Volume(issue)/page/year: 43,547,1993 1951-

TYPE OF TEST ROUTE OF EXPOSURE SPECIES OBSERVED DOSE/DURATION TOXIC EFFECTS :

: LD50 - Lethal dose, 50 percent kill : Unreported : Rodent - rat : >10 gm/kg

Details of toxic effects not reported other than lethal dose value REFERENCE : DIFREZ Diabetes Frontier. (Medikaru Rebyusha, Yoshida Bldg., 1-7-3 Hirano-machi, Chuo-ku, Osaka, 541, Japan) V.1Volume(issue)/page/year: 3,565,1992 1990-

TYPE OF TEST ROUTE OF EXPOSURE SPECIES OBSERVED DOSE/DURATION TOXIC EFFECTS :

: LD50 - Lethal dose, 50 percent kill : Unreported : Rodent - mouse : >10 gm/kg

Details of toxic effects not reported other than lethal dose value REFERENCE : DIFREZ Diabetes Frontier. (Medikaru Rebyusha, Yoshida Bldg., 1-7-3 Hirano-machi, Chuo-ku, Osaka, 541, Japan) V.1Volume(issue)/page/year: 3,565,1992 1990-

** REPRODUCTIVE DATA **

TYPE OF TEST ROUTE OF EXPOSURE SPECIES OBSERVED DOSE SEX/DURATION TOXIC EFFECTS :

: TDLo - Lowest published toxic dose : Oral : Rodent - rabbit : 254 ug/kg : female 7-18 day(s) after conception

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion Reproductive - Fertility - other measures of fertility REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1Volume(issue)/page/year: 27,1477,1993 1960-

*** END OF RECORD ***