Penyakit Kulit Alergi

Allergic Reactions
Immune system naturally responds to foreign substances in body Allergic reaction: exaggerated response to foreign substance Allergen: substance causing exaggerated effect

Classification of Immunologic Reactions (Gel and Coombs)

Hypersensitivity Reactions

Atopy
Atopy is the term for the genetic trait to have a predisposition for localized anaphylaxis. Atopic individuals have higher levels of IgE and eosinophils.

Urticaria
Wheal and flare
pale centers surrounded by rings of

erythemamore uniformly pink in color Itching resolve completely within 24 hours

Urticaria
Mast cell degranulation
physical factors Medications Infections Foods

Urticaria
Treatment Eliminating non-sedating anti-histamines sedating anti-histamines Corticosteroid

Signs and Symptoms: Hives

Urticaria - dermatographism
Type 1 prick

tests immediate

Atopic dermatitis
a chronic, relapsing skin disorder that

often begins in childhood, improves with age, but often manifests itself in adulthood with a relapsing course.

Atopic dermatitis
Acute lesion: pruritic, erythematous

macules or papules excoriated papules with crust and serum exudates

Diagnosis

Atopic dermatitis
Treatment relief of pruritus restoration of the barrier function of skin elimination of environmental factors that exacerbate AD amelioration of the inflammation

Food Hypersensitivity

Contact Dermatitis
eczematous rash site of contact any site affected, hands and face allergic; type IV cell-mediated hypersensitivity reaction following sensitisation eg; cosmetics, nickel,