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(19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0250145 A1
Sharma et al.
(54)
BIOLUMINESCENCE IMAGING OF
(75)
Inventors:
Vij ay Sharma, WildWood, MO (US); Seth Gammon, St. Louis, MO (US); David PiWnica-Worms, Ladue, MO (US); Shimon Gross, Yavne (IL)
(51)
Int. Cl. A61K 49/00 C07D 413/14 C07D 405/12 C07D 403/14 C07D 237/32 C07D 491/22
(52)
13/127,448
Nov. 3, 2009
PCT/US2009/063186
can be used for imaging sites of in?ammation and other pathological conditions associated With abnormal levels of MPO activity in vivo. Methods of synthesis of luminol ana
logues are also disclosed.
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