Brand name: Diflucan

Generic name: Fluconazole

Drug Classification: Antibiotics (Antifungal)
Indication: Adult: Oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlife-
threatening Candida infections (cystitis, esophaglitis); treatment of hepatosplenic candidiasis
and other Candida infections in person unable to tolerate amphotericin B; treatment of
cryptococcal infections; secondary prophylaxis in allogeneic bone marrow transplant
recipients.
Mechanism of action: Interferes with cytochrome P-450 activity, decreasing ergosterol synthesis
(principal sterol in fungal cell membrane) and inhibiting cell membrane formation.
Dose: Adult Candidiasis, disseminated candidiasis & other invasive candidal infection 400 mg on the 1 st
day followed by 200 mg daily. Vaginal candidiasis150 mg as single oral dose. Oropharyngeal-
candidiasis 50 mg once daily for 7-14 days. If necessary, continue treatment for longer periods
in patients w/ severely compromised immune function. Candidal infection of mucosa 50 mg
daily for 14- 30 days, may be increased up to 100 mg daily. Children mucosal candidiasis 3
mg/kg. Systemic candidiasis 6-12 mg/kg daily. Prevention of candidiasis based on risk o
developing fungal infections 50-400 mg once daily. Deep endemic mycoses200-400 mg daily
for up to 2 yr. Cryptococcal meningitis & cryptococcal infections at other sites 400 mg on the
1st day followed by 200- 400 once daily for atleast 6-8 wk. Prevention of relapse of
cryptococcal meningitis in patients w/ AIDS 200 mg daily after a full course of primary
therapy. Atrophic oral candidiasis associated with dentures 50 mg once daily for 14 days
concurrently w/ local antiseptic measures to the denture. Dermal infection including tinea
 pedis, corporis, cruris & candida infections 150 mg once wkly or 50 mg once daily for 2-4 wk
(tinea pedis: up to 6 wk). Tinea vesicolor 50 mg once daily for 2-4 wk.
Contraindication: Known hypersensitivity to fluconazole or other azoles; concomitant administration
with terfenadine.
Special Precaution: Pregnancy, lactation
Adverse Reactions:
CNS: headache
GI: hepatotoxicity, abdominal discomfort, diarrhea, nausea, vomiting
Derm: exfoliative skin disorder including Stevens - Johnson syndrome.
Drug Interaction: Warfarin, oral sulfonylureas, phenytoin, rifampicin, cyclosporin, theophylline,
terfenadine, zidovudine, OC.
Form: Capsule- 50mg, 150mg, 200mg; vial- 2mg/mL
Pregnancy Risk Category: C
Nursing Responsibilities:
 Assess infected area and monitor CSF cultures before and periodically during therapy.
 Monitor BUN and serum creatinine before and periodically during therapy.
 Monitor liver function tests before and periodically during therapy.