Cancer and cell senescence, correlation and impact: does the cancer effected by cell senescence, when and

how ?
Nermin khalaily

Abstract

Objectives: Cancer is the most famous of idiopathic diseases in the world, the main case is unknown however, there are some theories of etiology and risk factor that influence the development of cancer one of them is cell senescence. The objective of this study was to investigate the correlation between the cancer and cell senescence in mice and human. Methods: The base is to study the correlation of cancer incidence and ageing, by collecting information about the cancer incidence in different period of life from birth until maximum lifespan of human 100-120. Also to study the cancer incidence and ageing in mice, the same like human from birth until maximum lifespan (3-4) years. To compare between the results and the knowledge of pathogenesis of cancer and cell senescence. Results: After designing the graph which represent the relation of cancer and aging we notice Cancer incidence rises exponentially with age, beginning at about the mid-point of the maximum lifespan of the species starting from age 60 in human which correspond to initiation of physiological cell senescence and 18 month in mice. Similarly, cancer incidence is strongly influenced by external or environmental factors, such as exposure to mutagens or toxins, or conditions that stimulate chronic cell proliferation (for example, chronic inflammation or lytic infections). The survival rate increases while the age is increasing, in both human and mice.

Conclusion: There is exponentially correlation and impact between cell senescence and cancer. The cancer incidence increase when cell senescence is remarkable. The information was conformed for both species (human and mice).