Succinate

FADH2 H+ H+ H+

H+

H+

4H

Complex II
Succinate-CoQ Reductase

4H+

2H+

H 2O O2

EXAM 3 CHAPTERS 5 & 6

NADH

Complex 1
NADH-CoQ Reductase

CoQ

Complex III
Ubiquinone CoQ
cyt b, cyt c1

cyt c

Complex IV
Cyt C Oxidase
cyt a, cyt a3, Cu

X
Rotenone Amytal Piericidin

X
Antimycin

X
Carbon Monoxide Cyanide Azide
ADP + Pi ATP

F1 F0

H+
in cell pancreatic lipase pancreatic lipase fattyy acyl CoA synthetase

FA + ATP 2-MAG + FA PiPi

inorganic phosphatase

FA Adenylate
CoASH fatty acyl CoA synthetase AMP

TAG

DAG

C-II

B100

ApoC-II

B100

ApoE

B100
TAG<<CE

2 Pi
into liver by remnant receptor

(2) Acyl CoA + 2-MAG

acyltransferase ApoB48

TAG>>CE

LPL
FA

TAG=CE

HTGL

VLDL

IDL

LDL

FA

Free cholesterol and Fatty Acids

chylomicron remnants FAs and glycerol

ApoCII + ApoE lipoprotein lipase

TAG + 2CoASH
chylomicron

Glycerol
ATP

carnitine CoA
ADP

outside mitochondria

inside mitochondria

NADH NAD+

2FA CoA2 CoA

Acyl CoA

DHAP

G3P
CTP PiPi

Phosphatidic Acid

carnitine acyltransferase I

acylcarnitine
translocase

acylcarnitine carnitine

CATII

acyl-CoA
Fatty acyl-CoA dehydrogenase

FAD

citrate
DAG
G3P

FADH2

CDP-diacylglycerol
inositol CoA

trans-enol CoA
citrate lyase

Phosphatidylnositol PG-phosphate

TAG
acetyl CoA carboxylase

fatty acyl CoA + (2) acetyl-CoA

thiolase

H2O NADH + H+ NAD

+

Enol Hydratase

B-keto thiolase

3-keto fatty acyl CoA

L-3-hyrdoxyacyl CoA

L-3-OH dehydrogenase
acetyl CoA

phosphatase

Malonyl CoA

CoASH Acetyl CoA CoASH

phosphitidylglycerol(PG) + Pi
CDP-DAG

Acetoacetyl CoA
HMG CoA synthase
2NADPH + H+
+ NADPH 2NADP

HMG CoA
HMG CoA Reductase

HMG CoA lysase NADH + H+

NAD CO2
+

acetoacetate
B-hydroxy butyrate dehydrogenase

Cardiolipin

7a-hydroxycholesterol
H2O O2 + H+ cytoP450-Fe3+

acetone Melavonic Acid +

B-hyrdoxybutarate isopentenyl pyrophosphate

cytoP450-Fe

2+

NADP+ + H

3ATP

3ADP + 3Pi

DPP

cholesterol
3Cs

Lanosterol
squalene 2,3oxide cyclase

PiPi + Geranyl Pyrophosphate (C10)

IPP
NADP+ + 2PiPi NADPH + H+

Squalene Epoxide
Taylor A. Horst M'08

NADPH O2

PiPi

Squalene

Farnesyl Pyrophosphate (C15)

C15

isoprenoids

dolichol