PLATFORM BIOREACTORS TO FACILITATE REGENERATIVE MEDICINE EFFORTS

Lee Sierad
lsierad@g.clemson.edu

OUR GOALS
Provide a system that allows researchers to test and create living cardiovascular replacements
Heart valves, blood vessels, etc

Support regenerative medicine research by adapting our products and technologies to fit each researchers specific needs

MORE THAN THE STATUS QUO

Standard 2D and 3D culture environments are inadequate models for whole-tissue culturing
Apply limited mechanical forces Directed at cellular response, not tissue development All tissue-engineered products need pre-conditioning

Cardiovascular bioreactor options are scarce

Most created by research labs dont fully represent the blood flow seen in the body No adequate commercial option

WE HAVE A COMPETITIVE ADVANTAGE

Sterile Environment Stroke Volume Pulse Rate Simplicity of assembly

<30 minutes

TISSUE ENGINEERING & REGENERATION IN 2016

Global Market $89.7Billion
U.S. $40.4Billion
CV Devices $1.7Billion

Europe $36.1Billion

Rest of World $13.1Billion

Source: BCC Research 2012

ADVANTAGES FOR APTUS MARKET ENTRY

Seven years of university research
Third-generation, sophisticated, platform system made for easy assembly and use Universal LabView software and hardware for system monitoring and control

Extensive experience and knowledge in the field for use in customer support

IP portfolio covering trademarks, copyrights, and three pending patents

POTENTIAL FOR EXPANSION

Additional modules
Pulmonary/aortic valves Small diameter blood vessels Aortic aneurysms Mitral valves TAVI implantation tests

Sale of consumables Customization and service Drug and diagnostics testing

WHATS NEXT?
File patents and determine license agreements with Clemson University Research Foundation Secure initial funding through small business and SBIR/STTR grants Fulfill first order for waiting customer then finalize additional modules

Looking for additional partners to expand our applications, market segments, and network

PROVEN SUCCESS

Looking for additional partners to expand our applications, market segments, and network

Lee Sierad lsierad@g.clemson.edu 864-986-0533