Overview

- Ascomycota
o Sexual: Ascospores
o Asexual: Conidia
- Basidiomycota
o Sexual: Basidia
o Asexual: Clamp connection
- Zygomycota:
o Sexual and Asexual: Sporangiospores
Cutaneous infections
- Ascomycota: Dermatophytes
- Basidiomycota: Malassezia furfur (Tinea versicolor)
Subcutaneous, Systemic, Opportunistic infections
- Ascomycota
o Dimorphic
Histoplasma
Coccoides
Paracoccoides
Blastomyces
Sporothrix
o Yeastli!e
Pneumocystis jirovecci
Candida albincans
o "oldli!e
Aspergillus
Chromoblastomycosis
- Basidiomycota: Cryptococcus
- Zygomycota: yogomycetes
OPPORTUNISTS: NEUTROPENIA !enera""y are
#$P#AE
#$%%& "ar! Tuttle
%un&us In vitro In vivo
Aspergillus,
Fusariosa
Septate hyphae
'ranching at () angles
Zygomycoses Aseptate* +ide* irregular
hyphae +ith
sporangiospores
Candidiasis Chlamydospores , a
resting spore seen in
un-avora'le conditions
li!e +hen you culture
Candida and reduce
nutrients
.seudohyphae ,
/longated 'udding
yeast
See yeast AN'
(yp(ae to&et(
OPPORTUNISTS: T)CE** 'E%ICIENC$ !enera""y are $EASTS
Cryptococcus /ncapsulated 'udding
yeast (0ndia 0n!)
/ncapsulated
'udding yeast
(0ndia 0n!)
Pneumocystis
s
Cannot 'e cultured1 Cyst seen +ith
Silver23iemsa
stain -rom
Bronchoalveolar
4avage5 Cannot
'e cultured5
Microsporidos
is
/": Coiled polar
tu'ule helps
invade cells (since
it multiplies
intracellularly)
TRUE PAT#O!ENS A** ARE 'I+ORP#IC, #$%%& "ar! Tuttle
%un&us In vitro In vivo
Histoplasma Tu'erculate hyphae Budding yeast
Can 'e seen
intracellularly in
macrophages
(silver stain)
Coccoides Arthrospores -orm
septate hyphae
Spherules -illed
+ith endospores
Blastomyces Conidiophores Budding yeast
Paracoccoide
s
Conidiophores "ultipolar 'udding
yeast1
Sporothrix Canidiophores Cigarshaped
Yeast
CUTANEOUS IN%ECTIONS
%un&us In vitro In vivo
Tinea versico"or See yeast A6D
mold (hyphae)
SU-CUTANEOUS IN%ECTIONS
C(romob"astomycos
is
6aturally 'ro+n
sclerotic 'odies in
789 mount
P(aeo(yp(omycosis 6aturally 'ro+n
hyphae in 789
mount