Aspirin/paracetamol/caffeine

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Aspirin/paracetamol/caffeine
Aspirin/paracetamol/caffeine
Combination of
Aspirin NSAID
Paracetamol Analgesic
Caffeine Stimulant
Clinical data
Trade names Excedrin
AHFS/Drugs.com
entry
[1]
Legal status OTC (US)
Routes Oral
Identifiers
ATC code
N02BA51
[2]
Aspirin/paracetamol/caffeine is a combination drug for the treatment of pain, especially tension headache and
migraine.
[3]
It is sold in the US under the trade name Excedrin, although not all products sold under this name
contain this combination.
Adverse effects
The recommended dosing has a low risk profile when taken occasionally in a well hydrated state. As with all
medications containing paracetamol (acetaminophen), concomitant use with alcohol carries a significant risk of
hepatotoxicity. The combination of paracetamol with aspirin also creates the risk of renal papillary necrosis if large
doses are taken chronically. This is due to the fact that paracetamol yields a toxic metabolite that can accumulate in
the kidney while aspirin works to deplete the glutathione stores necessary to oxidize it. Additionally, chronic aspirin
usage is associated with increased risk of gastrointestinal bleeding.
Chemical detection
The combination of these three compounds can be detected in pharmaceutical formulations, urine and blood serum in
trace quantities using electrochemical methods.
Other trade names
In Germany, this combination is sold as Chephapyrin, dolomo, Dolopyrin, HA-Tabletten N, Melabon, Neuralgin,
Novo Petrin, ratiopyrin, Thomapyrin CLASSIC, Thomapyrin INTENSIV, TITRALGAN, in Austria as Thomapyrin,
InfluASS, Irocophan, and in Russia as Citramon.
Aspirin/paracetamol/caffeine
2
References
[1] http:/ / www. drugs. com/ excedrin. html
[2] http:/ / www. whocc.no/ atc_ddd_index/ ?code=N02BA51
[3] [3] Drugs.com:
Article Sources and Contributors
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Article Sources and Contributors
Aspirin/paracetamol/caffeine Source: http://en.wikipedia.org/w/index.php?oldid=607096494 Contributors: Anypodetos
License
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