PCB3063 GENETICS FORM 1 EXAM1 Spring 2012

1. The intrepid scientist/explorer Ludwig Kenichi Tracey has come back from Stephanbugga Land with a new
life form. These critters make love in triplets. They are all triploids formed through the fusion of three
gametes, and gametic ratios are 1:1:1. The DNA from these critters is a
a. concatenation of amino acids.
b. methylated spiral.
c. triple helix.
d. double helix.
e. form of triangle with four sides.
2. Pigeons may exhibit a checkered or plain color pattern. In a series of matings the following data were
obtained.
checkered X checkered 118 checkered
plain X plain 163 plain
checkered X plain 121 checkered F1 pigeons
F1checkered X F1 checkered 149 checkered and 53 plain
A reasonable hypothesis to explain this data is that
a. color is not inherited in pigeons.
b. color is a single locus, two allele (checkered dominant) system.
c. color is a single locus, two allele (plain dominant) system.
d. color is a single locus, two allele (checkered recessive) system.
e. color is a three locus system with a 9:3:3:1 expectation.
3. The meiotic explanation of Mendels Law of Segregation is that
a. the genetic material duplicates once and the cell divides twice.
b. the homologous chromosomes pair at metaphase I and then disjoin.
c. the homologous chromosomes may undergo crossing over.
d. nonhomologous chromosomes exchange p and q arms.
e. daughter cells are haploid.
4. The meiotic explanation of Mendels Law of Independent Assortment is that
a. daughter cells are diploid.
b. the homologous chromosomes pair at metaphase I and then disjoin.
c. the homologous chromosomes may undergo crossing over.
d. nonhomologous chromosomes align at random at metaphase 1.
e. nonhomologous chromosomes exchange p and q arms.
5. At metaphase 1 a chromosome contains ___ chromatids and ___ DNA double helices.
a. 2 , 2 b. 2, 4 c. 1 , 1 d. 3, 3 e. none of these is correct
6. After pairing at metaphase I chromosomes disjoin
a. without centromeric fission. b. with chromatids together.
c. into opposite daughter cells. d. a,b & c are all true.
7. If a pair of chromosomes at metaphase I contain the alleles M & M in one chromosome and m & m in the
other chromosome, the first daughter cells will contain
a. either m & m or M & M
b. either M & m or m & M
c. M & m and mm & M
d. MM Mm mM and mm


9. During replication a guanine is erroneously paired with an adenine on one of the new strands. At the
completion of meiosis the two haploids from this replication will be ____ and ____.
a. AT TA b. AG AT c. CG AT d. CG CA
10. In about 85 % of Europeans, known as secretors, antigen A or B is found in saliva and other bodily fluids
of people who are A, B or AB. Fifteen percent of Europeans who do produce red cell antigens do not secrete;
they are nonsecretors. A woman who is an A secretor marries another A secretor. Their first child is an A
nonsecretor. This result suggests that
a. secretor is dominant b. infidelity has occurred c. secretor is recessive d. the couple is sterile e. b & d are both
true
11. Professor Fromstazh has been collecting data from couples known to be carriers or heterozygotes for the
STR gene wiser. The data collected look like this
CHILDREN's PHENOTYPES
WW Ww ww
121 249 130 500
The expected number of heterzygotes is
a. 250 b. 400 c.125 d. 249 e. 15
12. Using his one locus two allele hypothesis the expected number of ww
homozygotes is
a. 18 b. 36 c. 41.25 d. 18.33 e. 125
13. and the expected number of WW homozygotes is
a. 125 b. 19 c. 13. d. 36.75 e. 18.33
14. The chi-square value for goodness of fit of this data is
[ Chi-square = SUM (obs-exp)
2
/exp ]
a. 0.0 b. 3.84 c. 0.32 d. 55 e. 0.001
PROBABILITY
df 0.95 0.90 0.50 0.25 0.05

1 .004 .016 .455 1.32 3.84
2 .103 .211 1.39 2.77 5.99
3 .352 .584 2.37 4.11 7.81

15. Professor Fromstazhs hypothesis
a. is consistent with this data.
b. should be rejected, because it does not fit the data.
c. is untestable. d. a. & c e. a & b
16. Another group of geneticists studying the wiser like loci identified carrier parents only when they had at
least one child who was homozygous for the recessive allele. Looking only at families with two children, what
fraction of heterozygous X heterozygous marriages would be missed?
a. 1/3 b. 2/3 c. 9/16 d. 7/16 e. 3/4
17. A biochemical event occurs while maternal and paternal genomes are separated and causes differential,
rather than equal, expression of the allele in the offspring. Mice who receive an IGF2, insulin like growth factor
2, allele from the paternal parent and a mutant nonfunctional allele from the maternal parent are normal.
Progeny of the reciprocal cross are runts. The normal IGF2 allele is _________ in the male parent.
a. methylated b. hydroylated c. epilated
d. esterified e. not methylated
18.The chi-square distribution relates
a. genetics to statistics b. deviation from theoretical value to probability
c. observed to expected d. metaphase to telophase
e. bases to sugars
19. In a cross of black-feathered Andalusian chickens with a strain having splashed-white feathers all the F
1

chicks were slate blue. { black X white blue F
1
s } When the F
1
s were intercrossed the chicks were 193
black, 409 blue and 198 white. Assuming that prior information had suggested single-locus codominance for
feather color, we would calculate _________ expected values. The total is 800 chicks.
a. 3:1 b. 1:1 c. 9:1 d. 1:2:1 e. 8:3
20. The expected number of blue chicks is
a. 600 b. 400 c. 198 d. 409 e. 193
21. The expected number of white chicks is
a. 600 b. 400 c. 200 d. 198 e. 193
22. The expected number of black chicks is
a. 600 b. 400 c. 200 d. 198 e. 193
23. The chi-square value for this test is
a. .47 b. 3.84 c. 9.74 d. 0.002 e. 9.4
-5-
Chi-square = SUM (obs-exp)
2
/exp
PROBABILITY
df 0.95 0.90 0.50 0.25 0.05

1 .004 .016 .455 1.32 3.84
2 .103 .211 1.39 2.77 5.99
3 .352 .584 2.37 4.11 7.81

24. The appropriate number of degrees of freedom for this test is
a. 1 b. 2 c. 1.5 d. 3 e. 0
25. The percentage of times one would expect to detect observed minus expected
discrepancies as large as these is
a. between 25 and 5 % b. less than 5% c. more than 95%
d. between 90 and 50% e. between 50 and 25%
26. In the Martin and Eaves study the data suggested that social attitudes were in large part inherited rather than
learned. This conclusion was based on
a. dominance effects at one locus.
b. greater resemblance between identical twins.
c. greater resemblance between identical twins.
d. 3:1 segragation ratio
e. cytoplasmic inheritance.
27. Alford and Hibbling subsequently found that approximately half of the variation in political attitudes was
genetically based, but _______ for party affiliation was found.
a. no genetic basis b. 50% genetic basis c. 40% genetic basis
d. imprinting e. complete genetic determination

GENETICS EXAM I 6 June 2001

1. Chromosomes, colored bodies, are composed of proteins and DNA; so are chromatids. At metaphase I there are 46
chromosomes aligned in pairs along the human cells equatorial plate. At this stage there are______chromatids.
a. 23 b. 46 c. 92 d. 8 e.16
5. The gametic ratio for a heterozygote is roughly 1:1, 1/2 : 1/2 or whatever expression you like for equivalence. This
results from a. anaphase I disjunction b. mitotic crossingover c. Chi-square degrees of freedom d. telomeric sequences
e. all of the above
7. Knowing that the segregation ratios for a set of loci are all 1/2 : 1/2, we can predict the frequencies of all possible
gametic types by multiplying, if the loci are on different chromosomes and independent. For an AaBbCcDd four locus
heterozygote there are ______ possible gametes of equal frequency. a. 2 b. 4 c. 8 d. 16 e. 32
24. Arthur Beaudet identified a young girl with CF and short stature. Since CF is a recessive he was surprised to find that
she had no paternal chromosome 7 alleles, but all of the other chromosomes showed paternal as well as maternal alleles.
The two CF alleles were both maternal. Engel in an 1980 issue of the American Journal of Medical Genetics described
this as _________________.
a. interchromosomal methylation b. meiotic arrest c. uniparental disomy d. semiconservative e. flibbertigibbitt
25. A biochemical event occurs while maternal and paternal genomes are separated and causes differential, rather than
equal, expression of the alleles in the offspring. Mice who receive an IGF2, insulin like growth factor 2, allele from the
paternal parent and a mutant nonfunctional allele from the maternal parent are growth-deficient. Progeny of the reciprocal
cross are normal. The normal IGF2 allele is _________ in the male parent.
a. somnubalated b. hydroylated c. epilated d. esterified e. methylated