Predisposing factors:

Open wounds/
vascular insufficiency disorders
genitourinary infections
respiratory infections
IV drug use
immunocompromising diseases
history of blood- stream infections
Indwelling prosthetic devices
fractures
Microorganisms gain entry
by way of blood
Microorganisms lodge into
an area where circulation
slows

Microorganisms grow

Increase pressure

fever, night sweats,

Vascular compromise
Ischemia
of the periosteum
Infection through the bone
cortex and marrow
Cortical devascularization
chills, restlessness,
nausea and malaise
constant bone pain,
swelling, tenderness,
warmth at the infection site,
restricted movement
of the affected part

Debridement necrosis

Formation of new bone Separation of devitalized

bone from living bone Sequestra

Involcrum Continues to be an
infected island

Difficulty to reach by
blood borne antibiotics

Enlarged sequestrum
Chronic stage

drainage from Development of sinus tract Sequestrum move

sinus tracts out to the soft tissue

Turns to scar tissue revascularized

Systemic signs may
be diminished with Site for continued Removal by the normal
constant bone pain, microorganism growth immune process
Swelling, tenderness,
warmth at the infection site
Remission and Healing
exacerbation

Excessive vascular
insufficiency

Loss of organ function Amputation