Holstein: Curriculum Vitae 1

Sarah E. Holstein, Ph.D.

Department of Psychology 4000 Troon Circle
Wofford College Apartment 24
429 N Church Street Boiling Springs, SC 29316
Spartanburg, SC 29303 Cell: (503) 704-3273
Office: (864) 597-4656
holsteinse@wofford.edu

EDUCATION

Ph.D., Behavioral Neuroscience 2002-2008
Oregon Health & Science University, Portland, Oregon

B.A., Psychology 1998-2002
Randolph-Macon Womans College, Lynchburg, Virginia
Honors in psychology, magna cum laude

ACADEMIC APPOINTMENTS

Adjunct Professor of Psychology 2013-present
Wofford College, Spartanburg, South Carolina

Visiting Lecturer in Psychology 2013
University of North Carolina at Chapel Hill

RESEARCH EXPERIENCE

Postdoctoral Research Fellow 2013-present
Wofford College
Advisor: David W. Pittman, Ph.D.
Topic: Contribution of the parabrachial nucleus to benzodiazepine-induced hyperphagia

Postdoctoral Research Fellow 2008-2013
University of North Carolina at Chapel Hill
Advisor: Clyde W. Hodge, Ph.D.
Topics: Behavioral and neurobiological substrates of binge alcohol drinking in adolescents,
developmental analysis of the prefrontal cortex proteome

Graduate Research Assistant 2002-2008
Oregon Health & Science University
Advisor: Tamara J. Phillips, Ph.D.
Dissertation Title: Contribution of GABA
B
receptors to acute ethanol sensitivity and as a
pharmacotherapeutic target

Undergraduate Researcher 2001-2002
Randolph-Macon Womans College
Advisor: Dennis M. Goff, Ph.D.
Honors Thesis Title: Elucidating the roles of dopamine, serotonin, and the 5-HT
2A
receptor
in ethanol preference
Holstein: Curriculum Vitae 2
TEACHING EXPERIENCE

I NSTRUCTOR OF RECORD
PSY 351 Psychopharmacology Fall 2014
Wofford College
A lecture/seminar hybrid course designed to introduce students to key concepts in
psychopharmacology through the use of lectures, class discussions, and analysis of primary
scientific research. I am solely responsible for the course design and content, including
creation of learning objectives, selection of primary source material and required texts,
writing and presentation of lectures, writing and evaluation of exams, and development and
evaluation of student writing assignments and presentations. Class size: 13 students.

PSY330L Behavioral Neuroscience Lab [*co-instructor of record] Fall 2014
Wofford College
A laboratory course designed to introduce students to advanced methods in behavioral
neuroscience research. As co-instructor for this course, I will be teaching students various
research methods in behavioral neuroscience, including rodent handling and behavioral
testing (conditioned taste aversion, evaluation of drinking and taste palatability), as well as
intracranial microinjection techniques. Class size: 8 students.

PSY 255 Introduction to Research Spring 2014
Wofford College
An independent study course designed to introduce students to experimental research in
psychology. During this course, students participated in ongoing research projects
examining the contribution of GABA signaling in the parabrachial nucleus to taste
processing using a rodent model. Class size: 2 students.

PSY 150 Introduction to Psychological Science and Lab Fall 2013 Spring 2014
Wofford College
A lecture and laboratory course designed to introduce students to key concepts in
psychology, as well as to the scientific method through the use of laboratory experiments
and APA-style lab reports. I was responsible for the writing and presentation of lectures,
writing and evaluation of exams, development of group exercises, modification of laboratory
experiments, and the design and evaluation of laboratory writing assignments and exercises.
Course / Instructor Rating (avg. across categories; class size 22-24 students) -
Fall 2013: 4.82 (out of 5) [92% response rate]
Spring 2014: 4.78 (out of 5) [82% response rate]

PSYC 220 Biopsychology Summer Sessions I and II 2013
University of North Carolina at Chapel Hill
A lecture-based course designed to introduce students to the biological bases of behavior
and disease. I was responsible for the course design and content, including creation of
learning objectives, selection of material and required texts, writing and presentation of
lectures, writing and evaluation of exams and reading quizzes, and development and
evaluation of writing assignments and group exercises. Class size: 10-11 students.
Course / Instructor Rating (avg. across categories; class size 10-11 students) -
Summer Session I: 4.77 (out of 5) [18% response rate]
Summer Session II: 4.86 (out of 5) [80% response rate]
Holstein: Curriculum Vitae 3
CO-FACI LI TATOR
BBSP 902 Responsible Conduct of Research 2009-2010
University of North Carolina at Chapel Hill
A discussion-based course for first-year graduate students in the biological and biomedical
sciences program designed to introduce students to issues in research ethics. With the course
co-facilitators, I was responsible for presenting topics, designing discussion exercises and
leading discussion among students.

GUEST LECTURER
PSYC 220 Biopsychology 2011-2012
University of North Carolina at Chapel Hill
Lectures on Hunger, Learning & Memory, Movement, and the Somatosensory System

GCEP 554 Addictions 2005-2006
George Fox University, Portland, Oregon
Lectures on the Biological Substrates of Addiction

TEACHI NG ASSI STANT
PSYC 101, 102 Introductory Psychology 2001-2002
Randolph-Macon Womans College

COURSES PREPARED TO TEACH
Addiction Behavioral Genetics Behavioral Neuroscience Introductory and Advanced
Neuroscience Introductory Psychology Learning and Conditioning Neurobiology of Disease
Neurochemistry Psychopharmacology Research Methods and Statistics (Neuroscience,
Psychology) Sensation and Perception Systems Neuroscience

RELEVANT GRADUATE COURSEWORK
Behavioral Genetics Behavioral Neuroscience Behavioral Psychopharmacology Cellular
Neurophysiology Learning and Conditioning Neurochemical Substrates of Addiction
Neurochemistry Statistics Systems Neuroscience

PEDAGOGI CAL TRAINI NG
Incorporating Writing in the Curriculum 2013
Wofford College
Workshop focused on strategies for incorporating writing instruction, practice, and peer
review into the curriculum.

College Science Teaching 2012
University of North Carolina at Chapel Hill
Semester-long seminar focused on teaching undergraduate students in the sciences. Topics
included designing learning objectives, assessing student learning, and incorporating active
learning strategies into the classroom.

Holstein: Curriculum Vitae 4
Becoming an Effective Research Mentor 2012
University of North Carolina at Chapel Hill
Workshop focused on maximizing student performance and satisfaction in the research lab.
Topics included setting expectations, designing effective research projects, and assessing
performance.

Center for Faculty Excellence Continuing Education Workshops 2009-2013
University of North Carolina at Chapel Hill
Workshops attended have included the neuroscience of student learning, creating dynamic
syllabi, writing learning objectives, student assessment strategies, creating teaching
portfolios, and leading discussion based courses.

RESEARCH MENTORI NG AND SUPERVI SI ON
Supervisor for Undergraduate Research 2013-present
Wofford College
Supervised 18 undergraduate research assistants in fall, interim, spring, and summer
semesters. Responsibilities included training students in rodent handling, behavioral testing,
microinjections, stereotaxic surgery, and histological analysis.

Research Mentor / Supervisor for Independent Honors Research Project 2013
Conor ONeill (University of North Carolina, Biology)
Title: Contribution of glycogen synthase kinase to the reinforcing properties of alcohol
Current Position: Medical student at Virginia Polytechnic Institute and State University

Research Mentor / Supervisor for Senior Honors Thesis Project 2012-2013
Amanda Small (University of North Carolina, Biology)
Title: Exploring the adolescent prefrontal cortical proteome and the developmental risk
factors for addiction
Current Position: Medical student at East Carolina University

Research Mentor / Supervisor for Undergraduate Research Assistants 2011-2013
University of North Carolina
Supervised 4 student research assistants and trained students in rodent handling, drug
injections, behavioral testing, tissue collection and processing, and western blot analysis.

Supervisor for Graduate Research Assistants 2008-2013
Abigail Agoglia (University of North Carolina, Neurobiology Curriculum)
Rebecca Fanelli (University of North Carolina, Neurobiology Curriculum)

AWARDS AND HONORS

Letter of Commendation for Teaching Excellence 2013
Department of Psychology, University of North Carolina at Chapel Hill
Recognition as one of the most effective teachers in Psychology for Summer Session II

Service to the University Award 2010
Office of Postdoctoral Affairs, University of North Carolina at Chapel Hill
Recognition for service as co-facilitator for BBSP902: Responsible Conduct of Research

Holstein: Curriculum Vitae 5
Junior Investigator Travel Award 2009-2012
Research Society on Alcoholism

Student Travel Award 2008
International Behavioural and Neural Genetics Society

Axon Award 2006
Oregon Chapter of the Society for Neuroscience
Award for one of four top research abstracts

Student Research Forum Award 2005
Oregon Health & Science University
Award for best oral presentation in research area

Student Merit Travel Award 2004-2007
Research Society on Alcoholism

Magna Cum Laude 2002
Randolph-Macon Womans College

Omicron Delta Kappa, National Leadership Honor Society 2001
Randolph-Macon Womans College

Psi Chi, National Honor Society in Psychology 2000
Randolph-Macon Womans College

RESEARCH FELLOWSHIPS AND GRANTS

Institutional Postdoctoral National Research Service Award T32AA007573 2010-2012
National Institute on Alcohol Abuse and Alcoholism

Dissertation Research Award 2006
American Psychological Association
First place award ($5000) to support a subset of my dissertation research

Individual Predoctoral National Research Service Award F31AA016031 2005-2007
National Institute on Alcohol Abuse and Alcoholism
Title: Role of GABA in the locomotor effects of ethanol - Holstein (PI)

Institutional Predoctoral National Research Service Award T32AA007468 2002-2005
National Institute on Alcohol Abuse and Alcoholism

PUBLICATIONS

PEER-REVI EWED PUBLI CATI ONS
Holstein, S.E., Mickley Steinmetz, K.R.., & Miles, J.E. (2014). Teaching science writing in an
introductory laboratory course. Manuscript submitted for publication.



Holstein: Curriculum Vitae 6
Holstein, S.E., Li, N., Eshleman, A.J., & Phillips, T.J. (2013). GABA
B
receptor activation
attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice.
Behavioural Brain Research, 237, 49-58.

Holstein, S.E.
*
, Spanos, M.
*
, & Hodge, C.W. (2011). Adolescent C57BL/6J mice show elevated
alcohol intake, but reduced taste aversion, as compared to adults: A potential behavioral
mechanism for binge drinking. Alcoholism: Clinical and Experimental Research, 35, 1842-
1851. [
*
denotes co-first authors]

Holstein, S.E., Dobbs, L., & Phillips, T.J. (2009). Attenuation of the stimulant response to ethanol
is associated with enhanced ataxia for a GABA
A
, but not a GABA
B
, receptor agonist.
Alcoholism: Clinical and Experimental Research, 33, 108-120.

Holstein, S.E. & Phillips, T.J. (2006). GABA
B
receptor stimulation accentuates the locomotor
effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol.
Pharmacology Biochemistry and Behavior, 85, 697-704.

Holstein, S.E., Pastor, R., Meyer, P.J., & Phillips, T.J. (2005). Naloxone does not attenuate the
locomotor effects of ethanol in FAST, SLOW or two heterogeneous stocks of mice.
Psychopharmacology, 182, 277-289.

Kamens, H.M., Phillips, T.J., Holstein, S.E., & Crabbe, J.C. (2005). Characterization of the parallel
rod floor apparatus to test motor incoordination in mice. Genes, Brain and Behavior, 4,
253-266.

PUBLI SHED ABSTRACTS AND POSTER PRESENTATI ONS

**
Denotes undergraduate research mentee,
+
denotes graduate research mentee

Baird, J.P., Swick, J., Nelson, T.S.
**
, Holstein, S.E., & Pittman, D.W. (2014, April). Selective
stimulation of GABA-A
2/3
receptors increases intake and motivation to consume sucrose
solution in rats. Poster presented at the annual meeting of the Association for
Chemoreception Sciences, Bonita Springs, FL.

Pittman, D.W., Holstein, S.E., Atkins, S.R.
**
, Nelson, T.S.
**
, Pence, L.J.
**
, Smith, K.A.
**
, Brantly,
A.M.
**
, Evans, S.M.
**
, Sidden, E.A.
**
, Smith, A.L.
**
, & Baird, J.P. (2014, April).
Stimulation of GABA-A in the parabrachial nucleus enhances taste palatability during long-
term and brief-access testing in rats. Poster presented at the annual meeting of the
Association for Chemoreception Sciences, Bonita Springs, FL.

Nelson, T.S.
**,
, Swick, J.C., Holstein, S.E., Pittman, D.W., & Baird, J.P. (2014, March). Selective
activation of alpha-2/3/5-containing GABA-A receptors increases intake and motivation for
a sucrose solution, but not taste palatability. Poster presented at the annual meeting of the
Symposium for Young Neuroscientists and Professors of the SouthEast (SYNAPSE),
Asheville, NC. [

undergraduate presenting author]

Holstein, S.E., Small, A.S.
**,
, Agoglia, A.E.
+
, Pillai, R., & Hodge, C.W. (2013). A proteomic
analysis of the adolescent and adult prefrontal cortex: Contribution of CB1 and calcineurin
signaling pathways to binge alcohol drinking. Alcoholism: Clinical and Experimental
Research, 37 (S2). [

undergraduate presenting author]

Holstein: Curriculum Vitae 7
Holstein, S.E. & Hodge, C.W. (2012). Adolescent C57BL/6J mice show reduced sensitivity to the
NR2B-NMDA receptor antagonist ifenprodil, as compared to adult mice. Alcoholism:
Clinical and Experimental Research, 36 (S1), 184A.

Holstein, S.E., Psilos, K.E., & Hodge, C.W. (2011). Contribution of metabotropic glutamate
receptors type I and II to binge alcohol consumption in adolescent and adult C57BL/6J
mice. Alcoholism: Clinical and Experimental Research, 35 (S6), 182A.

Psilos, K.E., Holstein, S.E., & Hodge, C.W. (2011). The ERK
1/2
MAPK signaling pathway, but not
the p38 MAPK pathway, specifically regulates binge alcohol drinking in adult C57BL/6J
mice. Alcoholism: Clinical and Experimental Research, 35 (S6), 182A.

Holstein, S.E. & Hodge, C.W. (2010). Investigating a functional association between neurogenesis
and behavioral sensitization to ethanol. Alcoholism: Clinical and Experimental Research, 34
(S6), 142A.

Spanos, M., Holstein, S.E., Lee, J., & Hodge, C.W. (2010). Differences in age related binge-like
ethanol consumption: Conditioned taste aversion as a possible behavioral mechanism.
Alcoholism: Clinical and Experimental Research, 34 (S6), 36A.

Holstein, S.E., Li, N., & Phillips, T.J. (2009). GABA
B
receptor activation does not reverse ethanol-
induced increases in nucleus accumbens dopamine in FAST mice. Alcoholism: Clinical and
Experimental Research, 33 (S6), 286A.

Holstein, S.E., Meyer, P.J., & Phillips, T.J. (2009). GABAergic and glutamatergic manipulations of
acute ethanol sensitivity: Primary blockade or accentuation of ataxia? Alcoholism: Clinical
and Experimental Research, 33 (S6), 214A.

Holstein, S.E., Stevenson, R.A., Stevenson, J.R., & Hodge, C.W. (2009). Behavioral sensitization
to ethanol is associated with a decrease in hippocampal neurogenesis in mice. Society for
Neuroscience Abstract Viewer & Itinerary Planner, No. 344.9.

Holstein, S.E., Kamens, H.M., Li, N., Eshleman. A.J., & Phillips, T.J. (2008). Evaluating the role
of GABA
B
receptors in ethanol sensitivity. Genes, Brain and Behavior.

Holstein, S.E., Dobbs, L., Li, N., McKinnon, C.S., Eshleman, A.J., & Phillips, T.J. (2007). GABA
system manipulations of ethanol stimulation: Primary blockade or accentuation of ataxia?
Alcoholism: Clinical and Experimental Research, 31 (S2), 148A.

Holstein, S.E. & Phillips, T.J. (2006). Contribution of GABA systems in sensitivity to the
locomotor stimulant effects of ethanol: effect of the GABA reuptake inhibitor NO-711.
Alcoholism: Clinical and Experimental Research, 30 (S6), 83A.

Holstein, S.E., Scibelli, A.C., McKinnon, C.S., & Phillips, T.J. (2006). Attenuation of ethanol-
induced locomotor stimulation by the GABA reuptake inhibitor NO-711 may be due to an
enhancement of ethanols ataxic effects. Society for Neuroscience Abstract Viewer &
Itinerary Planner, No. 193.14.



Holstein: Curriculum Vitae 8
Holstein, S.E., Pastor, R., Li, N., Reed, C., Aragon, C.M.G., & Phillips, T.J. (2005). Catalase
inhibition alters the locomotor stimulant effects of ethanol in FAST mice. Society for
Neuroscience Abstract Viewer & Itinerary Planner, No. 560.5.

Holstein, S.E., Pastor, R., Li, N., Reed, C., Aragon, C.M.G., & Phillips, T.J. (2005). The role of
brain ethanol metabolism in the locomotor effects of ethanol in the FAST and SLOW
selected mouse lines. Alcoholism: Clinical and Experimental Research, 29 (S5), 16A.

Holstein, S.E., Pastor, R., & Phillips, T.J. (2005). No effect of naloxone on the locomotor stimulant
effects of ethanol in FAST, Swiss or a heterogeneous stock of mice. Alcoholism: Clinical
and Experimental Research, 29 (S5), 145A.

Holstein, S.E., Meyer, P.J., & Phillips, T.J. (2004). Assessing the correlated trait of morphine
stimulation in FAST mice: role of the endogenous opioid system. Alcoholism: Clinical and
Experimental Research, 28 (S5), 61A.

Holstein, S.E., & Phillips, T.J. (2004). GABA
B
receptor activation enhances, rather than attenuates,
the locomotor stimulant effects of some morphine doses in FAST mice. Society for
Neuroscience Abstract Viewer & Itinerary Planner, No. 357.5.

PRESENTATIONS

RESEARCH TALKS: EXTERNAL
Research Society on Alcoholism 2010
San Antonio, Texas
Title: Investigating a functional association between neurogenesis and behavioral
sensitization to ethanol.

Research Society on Alcoholism 2009
San Diego, California
Title: GABAergic and glutamatergic manipulations of acute ethanol sensitivity: Primary
blockade or accentuation of ataxia?

International Behavioural and Neural Genetics Society 2008
Portland, Oregon
Title: Evaluating the role of GABA
B
receptors in ethanol sensitivity.

Bowles Center for Alcohol Studies, University of North Carolina 2007
Chapel Hill, North Carolina
Title: Exploring the contribution of GABA systems to acute ethanol sensitivity.

Ernest Gallo Clinic and Research Center, University of California, San Francisco 2007
Emeryville, California
Title: Exploring the contribution of GABA systems to acute ethanol sensitivity.

Symposium of the Oregon Chapter of the Society for Neuroscience 2006
Salishan Lodge, Oregon
Title: Contribution of GABA systems in sensitivity to the locomotor stimulant effects of
ethanol: Effect of the GABA reuptake inhibitor NO-711.
Holstein: Curriculum Vitae 9
Research Society on Alcoholism 2005
Santa Barbara, California
Title: No effect of naloxone on the locomotor stimulant effects of ethanol in FAST, Swiss or
a heterogeneous stock of mice.

National Institute on Alcohol Abuse and Alcoholism Trainee Conference 2003
Indianapolis, Indiana
Title: Assessing the correlated trait of morphine stimulation in FAST mice: Role of the
endogenous opioid system.

Virginia Psychological Association Symposium 2002
Virginia Beach, Virginia
Title: Elucidating the roles of dopamine, serotonin, and the 5-HT
2A
receptor in ethanol
preference.

RESEARCH TALKS: INTERNAL
Bowles Center for Alcohol Studies, University of North Carolina 2012
Chapel Hill, North Carolina
Title: Alcohol and adolescence: examining the pharmacological substrates underlying binge
drinking.

Department of Behavioral Neuroscience, Oregon Health & Science University 2008
Portland, Oregon
Title: Contribution of GABA
B
receptors to acute ethanol sensitivity and as a
pharmacotherapeutic target.

Student Research Forum, Oregon Health & Science University 2005
Portland, Oregon
Title: No effect of naloxone on the locomotor effects of ethanol in FAST, SLOW or two
heterogeneous lines of mice.

Department of Behavioral Neuroscience, Oregon Health & Science University 2004
Portland, Oregon
Title: Role of the endogenous opioid system and the GABA
B
receptor in the correlated
locomotor effects of ethanol and morphine in the FAST and SLOW selected lines.

SCIENTIFIC OUTREACH AND SERVICE

Brain Awareness Week 2014
Psychology Kingdom, Wofford College

Volunteer, Brain Lab 2012
Bowles Center for Alcohol Studies, University of North Carolina
Museum of Life and Science, Durham, North Carolina

Volunteer, Brain Bowl 2005-2006
Oregon Health & Science University
Game-show style neuroscience competition for high school students

Holstein: Curriculum Vitae 10
Volunteer, Alcohol and the Brain Booth 2005-2006
Portland Alcohol Research Center, Oregon Health & Science University
Oregon Museum of Science and Industry

Presenter, Using Your Marbles 2005
PAVTEC Math, Science, & Technology Conference for Middle School Girls
Portland Community College

Exhibitor, Kids Judge! Reverse Science Fair 2004
Oregon Health & Science University
Reverse science fair where 4
th
grade students judge the scientists

MEMBERSHIPS

Association for Chemoreception Sciences
Faculty for Undergraduate Neuroscience
Research Society on Alcoholism
Society for the Teaching of Psychology