INTRODUCTION

The early history of stereochemistry: From the discovery of molecular

asymmetry and the first resolution of a racemate by Pasteur to the asymmetrical
chiral carbon of vant Hoff and Le Bel.
Stereochemistrybasic terms and concepts
Molecular basis of chiral recognition

THE SEPARATION, PREPARATION, AND IDENTIFICATION OF

STEREOCHEMICALLY PURE DRUGS
Separation and resolution of enantiomers and their dissociable
diastereomers through direct crystallization
Indirect methods for the chromatographic resolution of drug enantiomers
HPLC chiral stationary phases for the stereochemical resolution
of enantiomeric compounds: The current state of the art.
Preparative and production scale chromatography in enantiomer
separations
Enantioselective separations by electromigration techniques

Alternative analytical techniques for determination or isolation of drug

enantiomers

Applications of stereochemistry in drug synthesis/designing.