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AP BIOLOGY/Culler

Unit 4 Cell Division and Introduction to Cell Communication


Learning Objectives
Essential knowledge 3.A.2: In eukaryotes, heritable information is passed to the next
generation via processes that include the cell cycle and mitosis.
1) LO 3.7 The student can make predictions about natural phenomena occurring during the cell
cycle. [See SP 6.4]
2) LO 3.8 The student can describe the events that occur in the cell cycle. [See SP 1.2]
3) LO 3.9 The student is able to construct an explanation, using visual representations or
narratives, as to how DNA in chromosomes is transmitted to the next generation via mitosis. [See
SP 6.2]
Essential knowledge 3.D.1: Cell communication processes share common features that reect a
shared evolutionary history.
4) LO 3.31 The student is able to describe basic chemical processes for cell
communication shared across evolutionary lines of descent. [See SP 7.2]
5) LO 3.32 The student is able to generate scientific questions involving cell communication
as it relates to the process of evolution. [See SP 3.1]
6) LO 3.33 The student is able to use representation(s) and appropriate models to describe
features of a cell signaling pathway. [See SP 1.4]
Essential knowledge 3.D.2: Cells communicate with each other through direct contact with other
cells or from a distance via chemical signaling.
7) LO 3.34 The student is able to construct explanations of cell communication through cell-tocell direct contact or through chemical signaling. [See SP 6.2]
8) LO 3.35 The student is able to create representation(s) that depict how cell-to-cell
communication occurs by direct contact or from a distance through chemical signaling. [See SP
1.1]
Essential knowledge 3.D.3: Signal transduction pathways link signal reception with cellular response.
9) LO 3.36 The student is able to describe a model that expresses the key elements of signal
transduction pathways by which a signal is converted to a cellular response. [See SP 1.5]

Essential knowledge 3.D.4: Changes in signal transduction pathways can alter cellular
response.
10) LO 3.37 The student is able to justify claims based on scientific evidence that changes in
signal transduction pathways can alter cellular response. [See SP 6.1]
11) LO 3.38 The student is able to describe a model that expresses key elements to show how
change in signal transduction can alter cellular response. [See SP 1.5]

12) LO 3.39 The student is able to construct an explanation of how certain drugs affect signal
reception and, consequently, signal transduction pathways. [See SP 6.2]
Reference chapters 11Cell Communication & 12 Cell Cycle
1st : Read chapter 11
Sketch Figure on p.208 and summarize and label each step
p. 235 Sketch cytokinesis plants vs animals
Chpt 11 Bookwork due: 1/28/15
p. 210 2, 3 p. 214 1
p. 219 2
p. 223 1
p. 225 1
p. 226-227 Chapter review practice questions due on day of test for EXTRA CREDIT
Chpt 12 Bookwork due: 2/9/15
p. 230 2
p. 238 6
p. 243 2, 4
p. 245 11
p. 244-245 chapter review practice questions due on day of test for EXTRA CREDIT
Cell Communication Activity 1/26 + 1/28
Cell division (mitosis) lab 2/5/15
TEST: 2/11/15

AP Biology
1- What do you remember about MITOSIS?

2- What do you remember about MEIOSIS?

Define:
1- cell cycle
2- cell plate
3- chromatid
4- centromere
5- crossing over
6- cytokinesis
7- diploid
8- gamete
9- haploid
10- homologous
11- mitosis
12- meiosis
13- zygote
Read p. chapters 11 & 12
Figure p. 208 SKETCH AND summarize AND LABEL each step
p. 235 Cytokinesis Plants VS Animals

Cell Communication
**External signals are converted into responses within the cell
Direct contact or by secrete local regulators (growth factors or neurotransmitters)
The 3 stages are reception: the target cells detection of a signal molecule
coming from outside
the cell, transduction: the conversion of the signal to a forma that can
bring about a
specific cellular response , response:the specific cellular response to the
signal molecule
RECEPTION:
Bind a signal molecule (ligand) and a receptor = SPECIFIC!!
Receptors found in 2 places: intracellular (hydrophobic, ex: testosterone or small NO)
Plasma membrane (receptors bind to water-soluble ligands)
How G-protein-couple receptors receive cell signals and start transduction
Step 1 the ligand binds to the G-protein-couple receptor
Conformational change in receoptor so it can bind to inactive G protein causing a
GTP to displace the GDP and therefore activates the G protein
Step 2 G protein binds to enzyme (activates)
Triggers next step in pathway leading to cellular response
Shape changes temporary
To continue new molecules required
nd
2 type of membrane protein = receptor tyrosine kinase
Step 1 binding dimer (each tyrosine kinase adds a (P) from ATP
Step 2 fully activated receptor protein initiates unique cellular response for each
phophorylatec
tyrosine
Ions are regulated by ligand-gated ion channels

TRANSDUCTION
Involve=phosphorylation cascade
Each step, protein kinases phosphorylate (activate proteins at next level)
LEADS to Large cellular response
-some involve small, nonprotein water-soluble molecules or ions called 2 nd messengers
RESPONSE
Regulate protein suynthesis turning genes on and off in nucleus
Final activated molecule in a signaling pathway functions as a transcription factor
APOPTOSIS (programmed cell death) integrates multiple cell signaling pathways
Systematically dismantled and digested
Protects neighboring cells from damage that would occur if a dying cell merely
leaked out its digestive and other enzymes
triggered by signals that activate a cascade of suicide proteins in cells
vert.=normal part of development essential for normal nervous system,
operation
of immune system and normal morphogenesis of hands and feet (humans)

AP BIOLOGY/Culler

Unit 4 Exam Review Cell Cycle and Cell Signaling

Multiple Choice
Amount of DNA during cell cycle
Cancer cells response
Check points in cell cycle
Data Analysis
Shared Characteristics between Prokaryotes and EukaryotesCell Division
Carcinogens
Protein Kinase Pathwayin a situation
Receptors on cells
Secondary Messengers
G protein pathway
Cell Communication basics
Interphase activities
Cell Communication Basics
Receptors and regulators
FRQ
Chromosome structure
Evolutionary significance
Differences between prokaryote and eukaryote
Short Answer
Signal Transduction Pathway
Cell Cycle RegulationCyclin and CdK
Grid-In
Mean
Chi Square

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