Modifiable:

-Environment
triggers
-hormones
-Infections
Drugs
UV radiation

Vascular Injury
Abnormal Constriction of Blood vessels
Overgrowth of endothelial & muscle of blood vessels
Endothelial cells dysfunction and activation

Corticosteroids

Modifiable:
- Medications
- Lifestyle
-Diet

Reduction in prostaglandin synthesis

Vasoactive mediators

Stomach mucosal barrier

Vasculopathy

Breakdown of mucosal barrier

Tissue hypoxia

Back diffusion of acid into gastric mucosa

Platelet activation

Pepsin Release
Histamine

Fibroblast activation
Overproduction of Collagen & and fibronectin in the dermis
Fibrosis of skin & organs

Acid secretion
Mucosal erosion
Vasodilatation
Destruction of blood vessels
Muscle spasm

Epidermal Atrophy

capillary permeability

Smooth muscle undergoes sclerosis atrophy & fibrosis

Inflammation of stomach mucosa

Epigastric pain

Luminal dilatation, reduced motility, Failure of the LES to relax

Delayed gastric emptying
Reflux of gastric contents to Esophagus (GERD)
Esophageal injury

Acute Gastritis

NonModifiable:
- Age
-Genetics
-