I want to check the correctness of 4-20mA signal in my measurement loop.

When
I connect the multimeter (in series) in the negative line it shows 16 mA. Whereas
on connecting the multimeter (in series) in the positive line it shows 0 mA. The
transmitter reading varies as per the process requirement.
Please help me as I am confused.
This often occurs in a panel where there are multiple loops connected to 1 I/O
module. There must be an alternative path for your positive line (some wire in
parallel). You need to make certain that the positive and negative current to/from
the transmitter in the field is in the same cable pair otherwise your signal is likely
to be noisy. Measure the positive and negative wire at the field device, there both
wires must be carrying the same current. If not, post a more detailed description
of your circuit.
Hope this helps.
Dear Sanat Sahu,
I think your instrument is not in working. It is internally short with ground. In 420mA loop positive and negative current should be same.
Zahid Ali Khan

What do you mean by connect to the positive line and negative line? You just do
the series connection, that is ok.