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patients, which hyperfractionation having the greatest benefit when comparing all types of
altered radiotherapy. 4
The clinical investigation done though the Department of Radiation Oncology group in
Atlanta,GA tested if local control rates were improved through altered radiation fractionation
schemes compared to standard fractionation of 70Gy. 1076 patients diagnosed with stage III and
IV squamous cell carcinoma were randomized into 4 treatment arms ranging from 42 Gy to 81.6
GY in a 6-7 week span. The results found, within this investigation, was significantly different
between patients at 5 years in the hyperfractionation arms compared to the standard arms.
Hyperfractionation overall survival rate was improved within these 5 years. In conclusion, local
regional control was improved without increasing late toxicity using hyperfractionation. 5