Predisposing:

Precipitating: fever
Interaction bet CNS and enteric NS

Brain communicates with the gut through multiple parallel pathways

including autonomic nervous system (ANS), the hypothalamic pituitaryadrenal axis (HPA), and other connections, which were termed the brain-gutaxis (BGA)
ENS regulatES the physiological gut functions including

secretion, motility and release of various

neuropeptides and hormones
Fever cause stress and tension that is responsible for the
dysregulation of the BGA,thus leading to increase strain in the
gut.
alterations of the brain-gut interactions("braingut axis")
activation of HPA involved in stress
response
stimulation of the hypothalamus leads
to CRF release
CRF has a potent effects on gut via modulation of
inflammation, increase of gut permeability, contribution to
visceral hypersensitivity (increased perception to pain) and
modulation of the gut motility
1alterations in gastrointestinal
motility;

2increase in visceral
perception;

3) changes in gastrointestinal
secretion;

4) increase in intestinal
permeability;

5) negative effects on regenerative

capacity of gastrointestinal mucosa and
mucosal blood flow;
negative effects on intestinal
microbiota.
bacteria may respond directly to stress-related
host signals.

catecholamines alter the growth, motility and virulence

of pathogenic and commensal bacteria.

profound effect on bacterial flora leading to increased adhesion

and translocation of bacteria due to increased barrier permeability.
Diarrhea
LAB RESULTS +NSG DX +
ASSESSMENT

TX: Importantly, this effect could be alleviated by

probiotics or antibiotics.