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Generic Name Brand Name Classification Mechanism of Action Contraindications Side Effects How Dosage & Nursing

Supplied Frequency Responsibilities


Ceftazidime Zeptrigen Antibiotic, Interfere with a final Patients with CNS: Headache, Injection: > Usual Dose: Before:
Cephalosphorin step formation of the allergies to dizziness,
(3rd Generation) bacterial cell wall penicillins, lethargies,
(inhibition of cepahlosporins. paresthesias, 1 gram Adults: 1 g 1. Assess for
mucopeptide malaise, fatigue, either IV or deep liver and renal
biosynthesis), resulting vertigo, 2 grams IM dysfunction.
in unstable cell confusion, administration
membranes that precipitation of every 8-12 hrs
undergo lysis. Also, seizures, Powder for depending on the
cell division and (especially in 2. Obtain CBC,
injection: type and severity renal function
growth are inhibited. clients with of infection.
impaired renal studies; reduce
More activity against function) dose with
gram-negative 500 mg dysfunction.
organisms and resistant >UTI’s
1 gram uncomplicated
organisms and les
activity against gram- GI: nausea,
vomiting, 2 grams 3. Culture
positive organisms infection, and
diarrhea, glossitis,
than first-generation abdominal 6 grams Adults: 250 mg arrange
drugs (Spratto and cramps or pain, IV or IM every sensitivity tests
Woods, 2008:1788). dyspepsia, 12 hrs before and
anorexia, during therapy if
flatulence,
cholestasis, expected
pseudomembrano >UTI’s response is not
us colitis complicated seen.

GU:
Nephrotoxicity Adults: 500 mg During:
IV or IM every
8-12 hrs
Hematologic:
1. Do not mix
leukopenia, with
leukocytosis, >Uncomplicated aminoglycoside
lymphocytosis, pneumonia, mild solutions,
neutropenia skin and skin administer these
(transient), structure drugs separately.
eosinophilia, infections
thrombocytopeni,
thrombocythemia, 2. Monitor
agranulocytosis, Adults: 500 mg- prothrombin
granulocytopenia, 1 g IV or IM time in patients
bone marrow every 8 hrs w/ renal or
depression, hepatic
hemolytic >Bone and joint impairment, in a
anemia, infections poor nutritional
pancytopenia, state or are on
decreased platelet prolonged
function, aplastic Adults: 2 g IV therapy.
anemia, every 12 hrs
hypoprothrom-
binemia (may
lead to bleeding) , 3. Preparation of
>Serious injectable
thrombocytosis
gynecologic or solution, sites
(transient)
intra-abdominal and methods of
infections, injection are
meningitis, treated with
Hypersensitivity: severe or life- utmost care.
urticaria, rashes threatening Administer IV
(maculopapular, infections in injection as
morbilliform, or immunocompro- slowly as
erythematous), mised clients possible.
pruritis (including
anal/genital
areas), fever,
Adults: 2 g IV After:
chills, erythema,
every 8 hrs
angioedema,
serum sickness,
joint pain, 1. Store at
exfoliative temperatures not
dermatitis, chest >Pseudomonal exceeding 30°C.
tightness, lung infections
myalgia, in cystic fibrosis
erythema clients with
normal renal 2. Have Vit. K
multiforme, available in case
edema, itching, function
hypoprothrombi
numbness, nemia occurs.
Stevens-Johnson
syndrome, Adults: 30-50
anaphylaxis mg/kg body
weight IV every 3. Discontinue if
8 hrs. Maximum hypersensitivity
Dose: 6 g/day occurs.
Hepatic:

hepatomegaly,
hepatitis

Local: Pain,
abscess at
injection site,
phlebitis,
inflammation at
IV site

Other:
Superinfections
including oral
candidiasis and
enterococcal
infections,
hypotension,
sweating, flushing
dyspnea,
interstitial
pnuemonitis,
disulfiram-like
reactions with
alcohol

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