Association of Genetic Variants of Hormonal Receptor Genes (ESR1 AND PGR) in

Gallbladder Cancer
Kiran Lata Sharma1, Anshika Srivastava1, Sanjeev Misra2, Ashok Kumar3, Neena Srivastava4, Balraj Mittal1
Department of 1Genetics and 3Gastroenterology
Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India
Department of 2Surgical Oncology, 4Physiology CSMMU, Lucknow, India

Gallbladder Cancer

RESULTS

GBC is an aggressive malignancy with dismal prognosis

Females 2-3 times more prone suggesting that sex hormones may
play a noteworthy role in the etiology of the disease
Hormonal factors as early age at first full-term birth, high parity, oral contraceptive
use and hormone replacement therapy, have been associated with higher rate of
GBC in women via increased estrogen and progesterone levels
Estrogen and progesterone receptors have been detected in human
gallbladder, suggesting their direct effect on gallbladder function

INCIDENCE

Very high
Moderately
high
Regional, very
high
in specific
Regional,
country
Moderately
high in specific
country

WORLDWIDE (FEMALES)

INDIA (FEMALES)

RISK FACTORS

HYPOTHESIS

OBJECTIVE

Inclusion Criteria

Inclusion criteria
CONTROLS

Details of selected genes

Age, Gender, Ethnicity matched

USG Negative
No Malignancy

CASES

Histopathologically proven

Conclusion

North Indian Ethnicity

The present findings suggest..

DEMOGRAPHY

CONTROLS

CASES

Gender

Gallstone

Age of Onset

OVERVIEW OF STUDY PLAN

Therefore, ESR1 PvuII C>T (rs 2234693) and Xba1 A>G

(rs9340799)
Susceptibility

Acknowledgements: Grant support from ICMR

may

be

evaluated

as

biomarkers

for

GBC