Test your Breast Cancer Knowledge: Questionaire

Stand / Letzte Aktualisierung durch Elisabeth Rieping 03.08.2005

Test your breast cancer knowledge! back

1. Which animals develop breast cancer? answers

a) Mice infected with the mouse mammary tumor virus?

b) cats, dogs and hedgehogs kept in captivity

c) cows infected with BLV?

d) rabbits infected with HTLV-1?

e) mice carrying the brca2 mutation

f) Sprague-Dawley rats treated with DMBA

2.Bone destruction develops in: answers

 a) persons with ATL (Acute T-cell Leukemia) after a HTLV-1 infection?

b) women with breast cancer?

c) cats with breast cancer ?

d) genetically engineered mice expressing the polyoma virus middle T antigen under the
control of a mouse mammary tumor virus promotor?

e) mice carrying the brca2 mutation?

3.Which assumption is correct? answers

a) In mice breast cancer incidence goes down with castration.

b) Castration of cats influences breast cancer incidence, if done before puberty.

c) Castration of cats with breast cancer influences their life expectancy.

d) Tamoxifen increases breast tumor incidence in the MMTV her2/neu transgenic mouse, if
given to very young mice.

e) Treatment of adult MMTV her2/neu mice with Tamoxifen results in a slow – down of
tumor formation.
4.What is wrong? Dexamethasone (Fortecortin) answers

a) a) induces mammary gland development

b) induces casein production in the mammary gland

c) induces mammary tumor viruses

d) induces iodine uptake to breast cancer cells

e) inhibits apoptosis

f) promotes none of the above mentioned activities

5. To analyse the influence of pregnancies on breast cancer development answers

a) one should compare the number of of pregnancies in women with breast cancer and
women without breast cancer.

b) one should compare only women with breast cancer and analyse the influence of birth
number on the time of breast cancer diagnosis.

c) one should analyse the influence of pregnancies on breast cancer appearance in BRCA 1
 and BRCA 2 mutation carriers.

d) one could look at cats with cancer of the udder and compare the age at diagnosis with the
number of pregnancies.

e) one should analyse the appearence of mammary neoplasms in mice, without knowledge on
their infection with MMTV.

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