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Pathogenesis of Preeclampsia

Unknown Etiology
Inadequate placentation

Uterine spiral arteries are poorly invaded


by cytotrophoblast

Uterine spiral arteries are poorly invaded


by cytotrophoblast

Cytotrophoblast failed to replace tunica


media

Incomplete pseudovascularization

Glomerular
endothelium is
damaged

Decreased placental perfusion


Constrictive properties of the arterioles
remained

Endothelial
dysfunction

vasoconstriction
Increase blood pressure

Filtration capacity
fails

proteinuria
edema