Waktu (hr)

Cp (mg/ml)
1
2
3
4
6
8
10

ln cp
72
4.2767
51
3.9318
33
3.4965
20
2.9957
14
2.6391
9
2.1972
4
1.3863

2.2796 t 1/2 (jam)

0.3040 K
5.1240 vd (L)
4.5807 Ln cpo
97.5794 cpo (mg/ml)
1.5577 Cl
2.2796 t1/2 el
320.9848 AUC

t vs ln Cp

4.5000
4.0000

f(x) = - 0.3043557125x + 4.4673431542

R = 0.9812541507

3.5000
3.0000

Column C

2.5000

Column C

Ln Cp
2.0000

Linear (Column C)

1.5000

Linear (Column C)

1.0000
0.5000
0.0000
0

4
6
time (hour)

10

12

po (mg/ml)

ln cpt=ln cpo-k.t
ln cpt+k.t=ln cpo
cl=k*vd
AUC=Cpo/K
0.693*Vd/Cl=t1/2 elim
Vd=Div/Cpo

Column C
Column C
Linear (Column C)
Linear (Column C)

t(jam)

Cp(mcg/mL)

Ln Cp

1
11.43
2
7.13
3
4.38
4
2.64
6
1.06
10
0.16
12
0.06
Obat Y dosis 500mg (IV bolus)

2.4362
1.9643
1.4770
0.9708
0.0583
-1.8326
-2.8134

k
t1/2
Ln Cpo
Cpo (mcg/ml)
Vd
Cl
t1/2elim
AUC

0.4750
1.4589
2.9112
18.3796
27.2041
12.9219
1.4589
38.6939

t Vs
3.0000
2.0000
1.0000
Ln Cp

f(x) = - 0.4756349822
R = 0.9999282826

0.0000
-1.0000 0

-2.0000
-3.0000
-4.0000
time

t Vs Ln Cp

000

000

000

f(x) = - 0.4756349822x + 2.9049694866

R = 0.9999282826
Column C

000

000 0

000

000

000
time

10

12

14

Linear (Column C)

t(jam)

Cp(mcg/mL)

1
2
3
4
6
10
12
Obat Z dosis 300mg (IV
k
t1/2
Ln Cpo
Cpo (mcg/ml)
Vd
Cl
t1/2elim
AUC

Ln Cp
4.82
4.26
3.42
2.68
1.84
0.81
0.53
bolus)

1.5728
1.4493
1.2296
0.9858
0.6098
-0.2107
-0.6349

t Vs Ln
2.0000
1.5000
1.0000
Ln Cp

0.2030
3.4138
1.7758
5.9048
50.8057
10.3136
3.4138
29.0879

f(x) = - 0.203593554x + 1.81

R = 0.9989925213

0.5000
0.0000
-0.5000

-1.0000
time

t Vs Ln Cp

f(x) = - 0.203593554x + 1.8197459646

R = 0.9989925213

Column C

Linear (Column C)

0
time

10

12

14

waktu (hari)

Cp (mg/L)

Ln Cp

0
0.25
0.5
0.75
1
1.5
3
6
12
18
24

0
0.901
1.309
1.526
1.577
1.429
0.964
0.384
0.062
0.01
0.002

Ln C'
0.0000
-0.1043
0.2693
0.4226
0.4555
0.3570
-0.0367
-0.9571
-2.7806
-4.6052
-6.2146

C'
0.6170
0.5455
0.4740
0.4025
0.3310
0.1880
-0.2410
-1.0990
-2.8150
-4.5310
-6.2470

1.8534
1.7255
1.6064
1.4956
1.3924
1.2068
0.7858
0.3332
0.0599
0.0108
0.0019

t vs Ln C res
1.0000
0.5000

f(x) = - 3.6593075031x + 0.6519378156

R = 0.9956434894

0.0000
Ln C Res
-0.5000

0.1

0.2

0.3

0.4

0.5

Column G
0.6

Linear (Column G)

-1.0000
-1.5000
Waktu (hour)

AUC
2
1.5
Cp

Column B

0.5
0
0

10

15
Waktu (hour)

20

25

30

C Res
1.8534
0.8245
0.2974
-0.0304
-0.1846
-0.2222
-0.1782
-0.0508
-0.0021
0.0008
-0.0001

0.6170
-0.1930
-1.2127

Ke
Ka
t1/2 el
AUC
Vd
Cl

-1.0000

0.2860
3.6590
2.4231
7.2894
43.1704
12.3467

t vs Ln C

0.0000
10

12

14

16

18

20

22

24

26

-2.0000

umn G

ear (Column G)

30

Ln C res

Ln Cp

-3.0000
-4.0000

f(x) = - 0.2861656004x + 0.6175144139

R = 0.9986937073
\

-5.0000
-6.0000
-7.0000
Waktu (hour)

Column B

Column C
Linear (Column C)

umn C

ear (Column C)

Dosis Obat 20mg peroral

Waktu (hour)

Cp (mg/L) Ln Cp
Ln C'
C'
0
0
0
-0.6220
0.25
0.264
-1.3318
-0.6643
0.5
0.379
-0.9702
-0.7065
0.75
0.406
-0.9014
-0.7488
1
0.414
-0.8819
-0.7910
1.5
0.395
-0.9289
-0.8755
3
0.309
-1.1744
-1.1290
6
0.189
-1.6660
-1.6360
12
0.069
-2.6736
-2.6500
18
0.026
-3.6497
-3.6640
24
0.009
-4.7105
-4.6780

C res
Ln C res
0.5369
0.5369
-0.622
0.5147
0.2507 -1.38366
0.4934
0.1144 -2.168334
0.4730
0.0670 -2.703699
0.4534
0.0394
0.4167
0.0217
0.3234
0.0144
0.1948
0.0058
0.0707
0.0017
0.0256
-0.0004
0.0093
0.0003

t vs Ln C res
0
-0.5
-1
Ln C res

0.1

0.2

0.3

0.4

0.5

f(x) = - 3.0926684962x - 0.6181643997

R = 0.999926174

-1.5
-2
-2.5
Waktu (hour)

0.6
Column G
Linear (Column G)

Column G

Linear (Column G)

Ke
Ka
t1/2 el
AUC
Vd
Cl

AUC

0.1690
3.0920
4.1006
2.9553
36.0406
6.0909

0.5
0.4
0.3
Cp

0.2
0.1
0
0

10

15

20

25

Waktu (hour)

t vs Ln C
0.0000
-1.0000

10

12

14

16

18

20

22

24

26
Column C

-2.0000
Ln Cp
-3.0000
-4.0000

f(x) = - 0.1697401606x - 0.6226231814

R = 0.9994217411

-5.0000
Waktu (hour)

Linear (Column C

AUC

Column B

15

20

25

tu (hour)

26

31814

Column C
Linear (Column C)

30

Obat V dosis 100 mg (PO)

Time (hr) Cp (mg/L)
ln Cp
ln C ekstraC ekstrapolC Res
0
0
0
2.731 15.34823 15.348227576
0.25
7.514 2.01676795
2.6565 14.24634 6.7323395495
0.5
10.296 2.33175547
2.582 13.22356 2.9275588479
0.75
11.039 2.40143446
2.5075 12.27421 1.2352061562
1
11.098 2.40676491
2.433 11.39301 0.2950098924
1.5
9.957 2.29827582
2.284 9.815865 -0.141134551
3
6.447 1.86361491
1.837 6.277677 -0.1693230476
6
2.633 0.96812388
0.943 2.567673 -0.065327106
12
0.43 -0.84397007
-0.845 0.429557 -0.0004426418
18
0.071 -2.6450754
-2.633 0.071863 0.0008625509
24
0.012 -4.42284863
-4.421 0.012022 2.220407E-005
ke
ka
t1/2 elimin
AUC
Vd
Cl

0.298
3.356
2.3255
50.7273
5.9537
1.7742

ln C Res
2.731
1.90692271
1.07416892
0.21123788
-1.2207464
Err:502
Err:502
Err:502
Err:502
-7.0556164
-10.715235

0
-1

10

16
t vs

12

14

f(x) = - 0.29
R = 0.99998
-2
2.5
f(x) = - 3.3568160569
ln Cp
2 -3R = 0.9998862721
3

1.5 -4
1
-5
0.5

ln C res

AUC
12

10

8
Cp

0.1

2
0
5

10

15
time

20

25

0.4

Linear (Colu

0.3

Columntime
B

f(x) = - 0.4075513495x + 7.8911764013

R = 0.4872658254

0.2

30

t vs ln Cp

10

16 ln
18 C20res
22
t vs

12

14

24

26

f(x) = - 0.2982398799x + 2.7310198045

R = 0.9999858327
2
(x) = - 3.3568160569x + 2.7396384002
R
3 = 0.9998862721

Column C
Linear (Column C)
Column G

Linear (Column G)

5
time
0.1

30

0.2

0.3

0.4

0.5

Columntime
B
Linear (Column B)

0.6

0.7

0.8

Obat W dosis 30 mg (per oral)

Time (hr) Cp (mg/L) ln Cp
ln C ekstrapolasi
C ekstrapolasi C Res
ln
0
0
0
-0.128
0.8799
0.8799
0.25
0.453 -0.791863
-0.15975
0.8524
0.3994
0.5
0.651 -0.429246
-0.1915
0.8257
0.1747
0.75
0.705 -0.349557
-0.22325
0.7999
0.0949
1
0.759 -0.275754
-0.255
0.7749
0.0159
1.5
0.725 -0.321584
-0.3185
0.7272
0.0022
3
0.616 -0.484508
-0.509
0.6011
-0.0149
6
0.411 -0.889162
-0.89
0.4107
-0.0003
12
0.19 -1.660731
-1.652
0.1917
0.0017
18
0.088 -2.430418
-2.414
0.0895
0.0015
24
0.041 -3.194183
-3.176
0.0418
0.0008

ke
ka
t1/2 elimin
AUC
Vd
Cl

0.127
3.002
5.4567
6.4884
32.7661
4.1613

C Res
-0.1280
-0.9179
-1.7446
-2.3548
-4.1404
-6.1017
Err:502
Err:502
-6.3972
-6.5315
-7.1923

t Vs ln Cp
0
-0.5 10

12

14

16

18

20

t22Vs24ln

-1 0.0000
ln Cp
0.8
0.7
0.6

0.1
0.2
0.3
0.4
0.5
f(x) = - 3.002799316x - 0.1602622
==- 0.9960129785
0.1277876671x - 0.128266286
-2 -0.5000f(x)R
R = 0.9999950278
-2.5
-1.0000
-3
-1.5

AUC

-3.5
-1.5000
f(x) = - 0.0237648425x + 0.5664767679
waktu (jam)
R = 0.4471367503
-2.0000

0.5
0.4
0.3
0.2

-2.5000

0.1
0
0

10

15

20

25

30

t Vs ln Cp
18

0.2

20

0.3

t22Vs24ln 26C Res

0.4

0.5

0.6

- 3.002799316x - 0.1602622017
AUC
1277876671x - 0.1282662864

9960129785
99950278

Column G
Linear (Column G)
Column B

679
ktu (jam)

20

Column
0.7
0.8C
Linear (Column C)

25

Linear (Column B)

30

obat A dosis 100 mg (p.o)

misal BA=90%

time (hr)

Cp (mg/L) Ln Cp
Ln C expol
C expol
C res
0
0
0
1.259
3.522
0.25
1.098
0.0935
1.2415
3.461
0.5
1.786
0.5800
1.224
3.401
0.75
2.24
0.8065
1.2065
3.342
1
2.529
0.9278
1.189
3.284
1.5
2.863
1.0519
1.154
3.171
3
2.955
1.0835
1.049
2.855
6
2.379
0.8667
0.839
2.314
12
1.528
0.4240
0.419
1.520
18
0.991
-0.0090
-0.001
0.999
24
0.66
-0.4155
-0.421
0.656

K (/jam)
0.07
Ka (/jam)
1.5374
t 1/2 el (jam
9.9
AUC (mg.ja 39.540625
Vd (L)
32.516
Cl (L/jam)
2.276

Vd=F*Dev/(K*AUC)
Cl=F*Dev/AUC

3.522
2.363
1.615
1.102
0.755
0.308
-0.100
-0.065
-0.008
0.008
-0.004

Ln C res
1.259
0.860
0.479
0.097
-0.281
-1.178

t vs Ln Cp

Ln C

0.5000
0.4000
0.3000
0.2000
0.1000
0.0000
10
-0.1000
-0.2000
-0.3000
-0.4000
-0.5000

f(x) = - 0.0699562612x + 1.2590138694

R = 0.9996672995

12

14

16

18

20

22

t
t vs Ln
C res
1.400
1.200

f(x) = - 1.5374190754x + 1.2514384037

R = 0.9999011601

1.000
0.800
Ln C res

0.600
0.400
0.200
0.000
-0.200

0.2

0.4

0.6

-0.400
time

0.8

vs Ln Cp

94

20

22

24

26

Column C
Linear (Column C)

C res

Column G
Linear (Column G)
Linear (Column G)
0.8

1.2

obat B dosis 25 mg (p.o)

time (hr)

Cp (mg/L) Ln Cp
Ln C expol C expol
C res
0
0
0
0.274
1.315
1.315
0.25
0.76
-0.274
0.238
1.268
0.508
0.5
1.025
0.025
0.202
1.223
0.198
0.75
1.123
0.116
0.166
1.180
0.057
1
1.118
0.112
0.129
1.138
0.020
1.5
1.066
0.064
0.057
1.059
-0.007
3
0.847
-0.166
-0.159
0.853
0.006
6
0.552
-0.594
-0.593
0.553
0.001
12
0.232
-1.461
-1.459
0.232
0.000
18
0.098
-2.323
-2.325
0.098
0.000
24
0.041
-3.194
-3.192
0.041
0.000

K (/jam)
Ka (/jam)
t 1/2 el (jam
AUC (mg.ja
Vd (L)
Cl (L/jam)

0.1444
3.7830
4.799
8.705
17.900
2.585

t vs Ln C
ln C res

0.000

0.274
-0.677
-1.618

10

12

14

16

18

20

-0.500
-1.000
Ln C

-1.500
-2.000

f(x) = - 0.1444304421x + 0.2737516508

R = 0.9999897188

-2.500
-3.000
-3.500
time

t vs Ln C res
0.500
0.000

f(x) = - 3.7829578852x + 0.2722374514

0 R = 0.9999918108
0.1
0.2
0.3

-0.500
Ln C res
-1.000
-1.500
-2.000
time

0.4

22

t vs Ln C
18

20

22

24

26

Column C
Linear (Column C)

2737516508

me

s Ln C res

0.3

0.4

0.5

0.6
Column G
Linear (Column G)

obat C dosis 200mg (PO)

time (hr)

Cp (mg/L) Ln Cp
ln C expol C expol
C res
Ln C res
0
0
0
3.502
33.185
33.185
3.502
0.25
11.858
2.473
3.438
31.113
19.255
2.958
0.5
17.63
2.870
3.373
29.170
11.540
2.446
0.75
20.814
3.036
3.309
27.349
6.535
1.877
1
21.298
3.059
3.244
25.641
4.343
1.5
21.071
3.048
3.115
22.539
1.468
3
14.872
2.699
2.728
15.308
0.436
6
6.88
1.929
1.955
7.062
0.182
12
1.501
0.406
0.407
1.503
0.002
18
0.321
-1.136
-1.140
0.320
-0.001
24
0.068
-2.688
-2.688
0.068
0.000

K (jam)
0.2579
Ka (/jam)
2.1547
t 1/2 el (jam
2.687
AUC
117.191
Vd
5.956
Cl
1.536

t vs ln Cp
1.000

AUC

0.500
0.000
-0.500 10
Ln Cp

f(x) = - 0.2578649272x + 3.502091964

25
12 R =
140.9999968663
16
18
20
22
24
26

-1.000

20

-1.500

15

-2.000

Cp

-2.500
-3.000

10

Colum

Linea

f(x) = - 0.7544725379x + 15.16933273

R = 0.473671096

5
time
0
0

10

15
time

t vs Ln C res
4.000
f(x) = - 2.1547089256x + 3.5037317718
R = 0.9996238832

3.000
Ln C res

Column G

2.000

Linear (Column G)

1.000
0.000
0

0.1

0.2

0.3

0.4

time

0.5

0.6

0.7

0.8

20

Cp
AUC

+ 3.502091964
22

24

26

Column C
Linear (Column C)
Column B

0.7544725379x + 15.1693327306
473671096

0.8

10

15
time

Column G
Linear (Column G)

20

Linear (Column B)

25

30

obat D dosis 10 mg (PO)

time (hr)

Cp (mg/L) ln Cp
Ln C expol
C expol
C res
ln C res
0
0
0
-1.184
0.306
0.306
-1.184
0.25
0.079
-2.538
-1.263
0.283
0.204
-1.590
0.5
0.122
-2.104
-1.342
0.261
0.139
-1.971
0.75
0.144
-1.938
-1.422
0.241
0.097
-2.329
1
0.157
-1.852
-1.501
0.223
0.066
1.5
0.153
-1.877
-1.659
0.190
0.037
3
0.109
-2.216
-2.135
0.118
0.009
6
0.045
-3.101
-3.087
0.046
0.001
12
0.007
-4.962
-4.990
0.007
0.000
18
0.001
-6.908
-6.893
0.001
0.000
24
0
0

K (/jam)
Ka (/jam)
t 1/2 el (jam
AUC
Vd
Cl

0.3172
1.5273
2.185
0.794
35.740
11.337

t vs ln Cp
0.000
-1.000 4
0.2
-2.000

10

12

AUC
14
16

t vs Ln C res

18

-3.000
f(x) = - 0.3172218741x - 1.1835685763
Ln 0.000
Cp 0.15
-4.000
R = 0.9998332113
0
0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8
-5.000
0.1
-0.500
Cp -6.000 f(x) = - 0.0054041438x + 0.1071888758
-7.000 R = 0.4631703226
-1.0000.05
-8.000
Ln C res
-1.500 0f(x) = - 1.5273430622x - 1.1959513665
time
R = 0.9991842809
0
5
10
15
20
25
-2.000
time
-2.500
time

t vs ln Cp

10

12

AUC
14
16

18

20

Ln C res

.3172218741x - 1.1835685763
98332113
.4 0.5 0.6 0.7 0.8
438x + 0.1071888758
6

2x - 1.1959513665
time
0
15
20
time

Column C
Linear (Column C)
Column B
Linear (Column B)
Column G
Linear (Column G)

25

30