Chronic Myeloid

Leukemia
By: Kiyahna Brown
Module: 1

Chronic Myeloid Leukemia {CML}

Blood cancer
Progressive disease
Bone marrow and other blood-forming
organs make increased numbers of
immature or abnormal leukocytes
(white blood cell)
Suppress production of normal blood
cells

Why Did I Choose to Research

Leukemia?
I knew a friend from my church that
had leukemia
Even though he was infected he had
the best attitude
I wanted to find out what was
happening to him inside

How Can You Get Leukemia?

Any blood-forming cells can turn into
leukemia cells
Leukemia cells cant mature
Over time, the cancer cells spread to
other parts of the body preventing the
other cells from working correctly

Connections To Genetics And

Mutagens

Mostly diagnosed by finding a specific

abnormality in the chromosomes
Scientists look for the Philadelphia chromosome
The philadelphia chromosome is made from
translocation of genetic material
The result gene codes that alerts signal
transduction pathways {a chemical reaction in
cells that transports info} and it leads to
uncontrollable growing cells

Symptoms And Survival Rate

weakness
fatigue
night sweats
weight loss
fever
bone pain
enlarged spleen
pain/sense of fullness in
belly
fullness after small amounts
of food

Chronic Phase:
4-5 years
Accelerated
Phase: unknown
Blastic Phase:
months usually

What Its Like For Someone With

This
People with this disease usually

have anxiety, fear, and emotional distress

no appetite
tired
are so tired that they fall
have a fever
are dehydrated
are losing hair
an insomniac {you cant sleep}

Treatments And Medications

Interferon
Chemotherapy
Radiation Therapy
Surgery
Stem Cell Transplant

Targets
Approx. 400 new cases are diagnosed
in CA. every year (all races included)
Rates increase with age
Rates are similar with gender and
races

Targets[p
The American Cancer Societys
estimates for CML in the US for 2014:

approx. 5,980 people will be diagnosed total

3,130 men
2,850 women
approx. 810 people will die total
550 men
260 women

Citations
"Google." Google. N.p., n.d. Web. 13 Nov. 2014.
National Center for Biotechnology Information
(US). Leukemia, Chronic Myeloid. U.S. National
Library of Medicine, 17 Jan. 0098. Web. 13 Nov.
2014.
"What Is Chronic Myeloid Leukemia?" What Is
Chronic Myeloid Leukemia? N.p., n.d. Web. 13
Nov. 2014.