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COW2

GracePansze
Period6

HowDNAWorks

1)
DNAcontainstwofundamentalstrandscallednucleotides(geneticcode)thatare
arrangedlikealadderthathasbeentwistedmultipletimesinthesamedirection.Thislatteris
calledthedoublehelixandisthebasicstructureofDNA.Thenucleotidesarethestepsofthe
latterandhydrogenbondsholdthemtogether(adenineonlywiththymine[AtoT],and
cytosineonlywithguanine[GtoC]).Thesugarphosphatecovalentbondsresemblehandrailsof
thelatter,calledsugarphosphatebackbone.Everynucleotidecontainsaphosphategroup,a
sugarmoleculeandoneoffourbases(nitrogenousbases):adenine,guanine,cytosine,or
thymine(DNAStructure).Purines(adenine,guanine)canonlyformahydrogenbondwith
pyrimidines(thymine,cytosine)toformnucleotides
(Classnotes,11/18)
.
"DNAStructure."
YouTube
.N.p.,13Sept.2006.Web.17Nov.2015.

2)
StepbystepDNAReplication
Step1:TheseparationofthetwoDNAstrands(sugarphosphate)atYfork(causedbygyrase)
bytheenzymehelicase.HelicaseunraveltheDNAstrands,splittingtheminhalf.Thisis
referredtoastheoriginorreplication.
Step2:RNAPrimase53and35templatesandparentchainsattractRNAnucleotides
(hydrogenbondbases)andtemporarilybindsRNAnucleotidestogether.RNAnucleotidesare
theprimersforDNAnucleotidesandarecalledsinglestrandbindingproteins(SSB)orRNA
primers.
Step3:Theelongationofthe53and35strandsbeginswiththeDNAPolymeraseadding
newnucleotidestothestrandtemplateandpairingthemwiththeirexistingcomplementary
nucleotides,(AwithT,GwithC).
Step4:DNAPolymerasereviewsDNAandremovesthetemporaryRNAPrimers.
Step5:DNAligasestitchesthestrandstogetherandsealsthem.
Step6:Theprocessrepeatsaftermechanismofrepairfixespossibleerrorsinthereplication.

Kyrk,John."StepsofDNAReplication."
StepsofDNAReplication
.N.p.,2006.Web.18Nov.
2015.

Freudenrich,Craig."HowDNAWorksArticle.docx."
GoogleDocs
.USNationalLibraryof

Medicine,n.d.Web.18Nov.2015.

3)
RNAtoDNATranscriptionProcessofEukaryoticCells
Step1:InthenucleustheenzymeRNAPolymerasebindsDNAtoasequenceofgenetic
codingreferredtoasthepromoter.
Step2:ThepromoterunravelsthetwoDNAstrands,separatingthem.
Step3:OneDNAstrandisusedasatemplatetocopynewnucleotidestocreateanewstrand.
Step4:Thenewnucleotidesarematchedwiththecomplementingnucleotides(GwithC,A
withU,RNAhasUracil,replacesthymine).
Step5:ThenewstrandsarebondedtogethertocreateacomplementarycopyoftheDNA
strand,alsoknownasthemRNA.
Step6:TheprocesscontinuesuntilmRNAencountersaterminationsequenceornucleotides.

Freudenrich,Craig."HowDNAWorksArticle.docx."
GoogleDocs
.USNationalLibraryof
Medicine,n.d.Web.18Nov.2015.

4)ExtraCredit(2pts):Whatdothefollowingcodonscodefor:UGGCAAAUUGCC?(Fun
Fact!TheproteinUGGcodesfortheproteinlocatedinturkeymeatthatmakesyousleepy.)
Thecodeis:
TryptophanGlutamineIsoleucineAlanine
HowDNAWorks
.2007.HowStuffWorks,n.p.

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