Beruflich Dokumente
Kultur Dokumente
B.S.
Biology
1990-1992
1992-1994
1994-2000
2002-2003
2003-2008
2009-2011
2011-
2002
University of California, San Francisco Science & Health Education Partnership Mentor
Award
2003
University of California, San Francisco Science & Health Education Partnership Mentor
Award
2005
2008
2010
2012
2012
PROFESSIONAL ACTIVITIES
Service to Professional Publications
2007 Federation of European Biochemical Societies (FEBS) (ad hoc reviewer)
2009
2011
2012
2013
2013 - Chemical Biology & Drug Design (CBDD) (ad hoc reviewer)
SERVICE
2002 Summer San Francisco Science & Health Education Partnership (Mentor)
2003
2004
Student Poster Reviewer for Career and Research Days sponsored by Graduate
Students Association (UCSF)
2006
Student Poster Reviewer for Career and Research Days sponsored by Graduate
Students Association (UCSF)
2007
2010
2010
2011
2012
2015
VTPREP-Search Committee
Summer Mentor for University of California Science & Education Partnership 2003
Summer Mentor for University of California Science & Education Partnership
2004
Student Poster Reviewer for Career and Research Days sponsored by Graduate
Students Association (UCSF)
2006
Student Poster Reviewer for Career and Research Days sponsored by Graduate
Students Association (UCSF)
Fall 2012
Fall 2012
Fall 2013
Fall 2014
Fall 2015
Fall 2015
INVITED PRESENTATIONS
2004 Gordon Research Conference on the Biology of Host-Parasite Interactions
Salve Regina College Newport R.I. June 27-July 2, (invited talk, poster)
Exploring TbCatB as a potential drug target against Trypanosoma brucei:
2005
2005
2005
2008
2008
2009
2012
2012
2013
2013
2013
2014
2014
2015
2015
2015
1997-1999
2000-2002
2003-2006
2006-2008
2007-2011
RESEARCH ARTICLES:
Wang YC. Burkhart WA. Mackey ZB. Moyer MB. Ramos W. Husain I. Chen J.
Besterman JM. Tomkinson AE. Mammalian DNA ligase II is highly homologous with vaccinia
DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation. J Biol
Chem. 269(50):31923-8, 1994 Dec 16.
Husain I. Tomkinson AE. Burkhart WA. Moyer MB. Ramos W. Mackey ZB.
Besterman JM. Chen J. Purification and characterization of DNA ligase III from bovine testes.
Homology with DNA ligase II and vaccinia DNA ligase. J Biol Chem. 270(16):9683-90, 1995
Apr 21.
Kamel D. Mackey ZB. Sjoblom T. Walter CA. McCarrey JR. Uitto L.
Palosaari H. Lahdetie J. Tomkinson AE. Syvaoja JE. Role of deoxyribonucleic acid
polymerase epsilon in spermatogenesis in mice. Biol Reprod. 57(6):1367-74, 1997 Dec.
Mackey ZB. Ramos W. Levin DS. Walter CA. McCarrey JR. Tomkinson AE.
An alternative splicing event, which occurs in mouse pachytene spermatocytes, generates a
form of DNA ligase III with distinct biochemical properties that may function in meiotic
recombination. Mol Cell Biol. 17(2):989-98, 1997 Feb. Tomkinson AE. Mackey ZB. Structure
and function of mammalian DNA ligases. Mutat Res. 407(1):1-9, 1998 Feb.
Chen J. Tomkinson AE. Ramos W. Mackey ZB. Danehower S. Walter CA.
Schultz RA. Besterman JM. Husain I. Mammalian DNA ligase III: molecular cloning,
chromosomal localization, and expression in spermatocytes undergoing meiotic recombination.
Mol Cell Biol. 15(10):5412-22, 1995 Oct.
Liu, Chao-lin; Shen, Chia-Rui; Hsu, Fong-Fu; Chen, Jeen-Kuan; Wu, Pei-Tzu; Guo, Shang-Hsin;
Lee, Wen-Chien; Yu, Feng-Wei; Mackey, Zachary B.; Turk, John; Gross, Michael L. Isolation
and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii
Submitted
Chen C-K, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KKH, et al. (2009) Trypanosoma cruzi
CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit. PLoS Negl Trop Dis
3(2): e372. 2009
Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas
schubertii. Liu CL, Shen CR, Hsu FF, Chen JK, Wu PT, Guo SH, Lee WC, Yu FW, Mackey ZB,
Turk J, Gross ML. Biotechnol Prog. 2009 Jan-Feb;25(1):124-31.
Oluwafemi AJ, Okanla EO, Camps P, Muoz-Torrerob D, Mackey ZB, Chiang PK, Seville S,
Wright CW. Evaluation of cryptolepine and huperzine derivatives as lead compounds towards
new agents for the treatment of human African trypanosomiasis. Nat Prod Commun. 2009
Feb;4(2):193-8.
Kerr ID, Wu P, Marion-Tsukamaki R, Mackey ZB, Brinen LS. Crystal Structures of TbCatB and
rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma
brucei. PLoS Negl Trop Dis. 2010 Jun 8;4(6):e701.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A,
Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor
library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023.
Mackey ZB, Koupparis K, Nishino M, McKerrow JH. High Throughput Analysis of an RNAi
Library Identifies Novel Kinase targets in Trypanosoma brucei.
Chem Biol Drug Des. Volume 78, Issue 3, pages 454463, September 2011
Lavrado J, Mackey ZB, Hansell E, McKerrow JH, Paulo A, Moreira R. Antitrypanosomal and
cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem
Lett. 2012 Oct 1;22(19):6256-60. doi:10.1016/ j.bmcl.2012.07.104.
Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L,
Clayton C, McKerrow JH, Linington RG. Examination of the Mode of Action of the Almiramide
Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei. J Nat Prod.
2013 Feb 27.
Frevert U, Movila, A, Nikolskaia O, Raper J, Mackey ZB, Abdulla M, McKerrow J and Grab DJ.
Early Invasion of Brain Parenchyma by African Trypanosomes PLoS One. 2012;7(8):e43913.
doi: 10.1371/journal.pone.0043913.
Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey
Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR.
Antimicrob Agents Chemother. A Cysteine Protease Inhibitor Rescues Mice from a Lethal
Cryptosporidium parvum Infection. 2013 Dec;57(12):6063-73. doi: 10.1128/AAC.00734-13.
Epub 2013 Sep 23.
Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct
mechanisms for inhibiting proliferation and cell cycle progression. Valenciano AL, Ramsey AC,
Mackey ZB. Cell Cycle. 2015;14(4):674-88. doi: 10.4161/15384101.2014.987611.
Submitted
TbERK8 phosphorylates TbPCNA at the unique insertion loop in its second domain
Ana L. Valenciano1, Nicole Olson2, Giselle M. Knudsen2, Charles S. Craik2, and Zachary B.
Mackey1
In Preparation
T2AA selectively inhibits HsPCNA but not TbPCNA. Ana L. Valenciano, Hyun Kang, Naoaki
Fujii, and Zachary B. Mackey*
AZ 960, a selective inhibitor of TbERK8 that has bioactivity against Trypanosoma brucei. Ana L.
Valenciano, Aaron C. Ramseys, William P. Janzen and Zachary B. Mackey