AKNE VULGARIS

dr.Mungky Sukarnadi

Initial pathogenesis (reason unknown):

follicular hyperkeratinization
proliferation +
decreased desquamation of keratinocytes
hyperkeratotic plug
(microcomedone)

Pathogenesis
Sebaceous glands enlarge
Sebum production increases
Growth medium for P. Acnes
plugs provide anaerobic
Lipid-rich environment

Pathogenesis
Bacteria thrive
Inflammation results
Chemotactic factors attract neutrophils
Depending on conditions
Non-inflammatory
open/closed comedones

Inflammatory papule/
pustule/nodule

Whitehead and blackheads

Closed comedones (whiteheads)

closed comedo
(a whitehead):
Accumulation of sebum
converts a
microcomedo into this.

Closed comedones (whiteheads)

Open comedo (blackhead)

open comedo
(a blackhead):
when follicular orifice is
opened + distended.
Melanin + packed
keratinocytes + oxidized
lipids dark colour

Open comedo (blackhead)

Pustular