1. 5% Amlexanox oral paste.

Dab applied to ulcers 4x/day until ulcers healed

or study ended. only agent that has a triple action in the form of preventing
recurrences, decreasing healing time and accelerating pain resolution.
2. Topical corticosteroids (TCs) remain the mainstays of treatment.
Hydrocortisone hemisuccinate pellets (Corlan), 2.5 mg used 4 times daily
Triamcinolone acetonide in carboxymethyl cellulose paste (Adcortyl in orabase
[withdrawn in some countries], Kenalog), administered 4 times daily
Betamethasone sodium phosphate as a 0.5-mg tablet dissolved in 15 mL of water
to make a mouth rinse, used 4 times daily for 4 minutes each time
3. 150 mg doxymycine + 1ml of 0.9% NaCl + 1 drop cryo. Topical tetracyclines
may reduce the severity of ulceration, but they do not alter the recurrence
rate. A doxycycline capsule of 100 mg in 10 mL of water administered as a
mouth rinse for 3 minutes or tetracycline 500 mg plus nicotinamide 500 mg
administered 4 times daily may provide relief and reduce ulcer duration
4. Topical 50mg penicillin G potassium troches (Cankercillin) applied 4x/day for 4
days
5. levamisole hydrochloride (150 mg) was administered once a week for one
month. Levamisole, an antihelminthic drug that can modulate immune
responses
6. Colchicine (0.6 mg 3 tid), Prednisone (20-80 mg/d), Azathioprine use (50
mg/d), Montelukast sodium (10 mg/d) has been reported as potentially
effective with fewer adverse effects than steroids.
7. Recommend the patient avoid using sodium lauryl sulfate. This agent is a
detergent found in most dentifrices, and it disrupts the surface of the
epithelium. Although it has not been proven causative in recurrent aphthous
ulcers, results are equivocal in whether elimination of the agent prevents
episodes of ulceration. Eliminating the agent may reduce pain and healing
time during outbreaks.
8. Topical querecitin may be a beneficial adjunct and slightly shorten healing
time
9. Nicotine replacement therapy may help ameliorate lesions that have resulted
from cessation of a tobacco habit
10.Avoid acidic foods such as citrus fruits, or spicy foods that may aggravate the
sore.